SMART accession number:SM00979
Description: This short possible domain is found in a variety of plant transcription factors that contain GATA domains as well as other motifs. Although previously known as the Zim domain this is now called the tify domain after its most conserved amino acids. TIFY proteins can be further classified into two groups depending on the presence (group I) or absence (group II) of a C2C2-GATA domain. Functional annotation of these proteins is still poor, but several screens revealed a link between TIFY proteins of group II and jasmonic acid-related stress response.
Interpro abstract (IPR010399):

The tify domain is a 36-amino acid domain only found among Embryophyta (land plants). It has been named after the most conserved amino acid pattern (TIF[F/Y]XG) it contains, but was previously known as the Zim domain. As the use of uppercase characters (TIFY) might imply that the domain is fully conserved across proteins, a lowercase lettering has been chosen in an attempt to highlight the reality of its natural variability.

Based on the domain architecture, tify domain containing proteins can be classified into two groups. Group I is formed by proteins possessing a CCT (CONSTANS, CO-like, and TOC1) domain and a GATA-type zinc finger in addition to the tify domain. Group II contains proteins characterised by the tify domain but lacking a GATA-type zinc finger. Tify domain containing proteins might be involved in developmental processes and some of them have features that are characteristic for transcription factors: a nuclear localisation and the presence of a putative DNA-binding domain [ (PUBMED:17499004) ]. Some proteins known to contain a tify domain include:

  • Arabidopsis thaliana GATA transcription factors (Zinc-finger protein expressed in Inflorescence Meristem, ZIM), a putative transcription factor involved in inflorescence and flower development [ (PUBMED:10945256) (PUBMED:14966217) ].
  • A. thaliana ZIM-like proteins (ZML) [ (PUBMED:14966217) ].
  • A. thaliana Protein TIFY 1-11 [ (PUBMED:16916932) ].

Family alignment:
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There are 1612 TIFY domains in 1592 proteins in SMART's nrdb database.

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