AdoHcyase_NADS-adenosyl-L-homocysteine hydrolase, NAD binding domain
|SMART accession number:||SM00997|
|Interpro abstract (IPR015878):|
S-adenosyl-L-homocysteine hydrolase (EC 220.127.116.11) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. AdoHcyase is an ubiquitous enzyme which binds and requires NAD+ as a cofactor. AdoHcyase is a highly conserved protein [(PUBMED:1631127)] of about 430 to 470 amino acids.
This entry represents the glycine-rich region in the central part of AdoHcyase, which is thought to be involved in NAD-binding [(PUBMED:1631127)].
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