Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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EPEND Ependymins

SMART accession number:	SM00026
Description:	Ependymins are the predominant proteins in the cerebrospinal fluid (CSF) of teleost fish. They have been implicated in the neurochemistry of memory and neuronal regeneration. They are glycoproteins of about 200 amino acids that can bind calcium. Four cysteines are conserved that probably form disulfide bonds.
Interpro abstract (IPR001299):	Ependymins are secretory proteins found predominantly in the cerebrospinal fluid of teleost fish [ (PUBMED:1831964) (PUBMED:8350351) ]. A bound form of the glycoproteins is associated with the extracellular matrix, probably with collagen fibrils, that may be the functional form of ependymins [ (PUBMED:8005346) ]. The proteins bind calcium via N-linked sialic acid residues. The molecular function of ependymins appear to be related to cell contact phenomena involving the extracellular matrix [ (PUBMED:8005346) ].
GO process:	cell-matrix adhesion (GO:0007160)
GO component:	extracellular region (GO:0005576)
GO function:	calcium ion binding (GO:0005509)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 92 EPEND domains in 91 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing EPEND domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with EPEND domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing EPEND domain in the selected taxonomic class.

• Links (links to other resources describing this domain)

• INTERPRO	IPR001299
  PROSITE	PS00899

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