PBPe

Eukaryotic homologues of bacterial periplasmic substrate binding proteins.
PBPe
SMART accession number:SM00079
Description: Prokaryotic homologues are represented by a separate alignment: PBPb
Interpro abstract (IPR001320): Ionotropic glutamate receptors (iGluRs) are a highly conserved family of ligand-gated ion channels present in animals, plants, and bacteria, which are best characterised for their roles in synaptic communication in vertebrate nervous systems [(PUBMED:14977400)]. A variant subfamily of iGluRs, the Ionotropic Receptors (IRs), consist of non-glutamate-binding chemosensory receptors first identified in Drosophila melanogaster. They function in detecting odors and tastants [(PUBMED:20808886)]. There are three classes of ionotropic glutamate receptors (iGluRs), namely NMDA (N-methyl-D-aspartate), AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid) and kainate receptors. They are believed to play critical roles in synaptic plasticity. At many synapses in the brain, transient activation of NMDA receptors leads to a persistent modification in the strength of synaptic transmission mediated by AMPA receptors and kainate receptors can act as the induction trigger for long-term changes in synaptic transmission [(PUBMED:10580501)].
GO component:membrane (GO:0016020)
GO function:ionotropic glutamate receptor activity (GO:0004970)
Family alignment:
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There are 3298 PBPe domains in 3286 proteins in SMART's nrdb database.

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