Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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BowB Bowman-Birk type proteinase inhibitor

SMART accession number:	SM00269
Description:	-
Interpro abstract (IPR000877):	This family of eukaryotic proteinase inhibitors, belongs to MEROPS inhibitor family I12, clan IF. They predominantly inhibit serine peptidases of the S1 family ( IPR001254 ) [ (PUBMED:14705960) ]. Exceptionally, cowpea trypsin inhibitor inhibits a cathepsin L-like cysteine proteinase CPL-1 from the nematode Heterodera glycines [ (PUBMED:8873479) ]. The Bowman-Birk inhibitor family [ (PUBMED:6996568) ] is one of the numerous families of serine proteinase inhibitors. They have a duplicated structure and generally possess two distinct inhibitory sites. These inhibitors are primarily found in plants and in particular in the seeds of legumes as well as in cereal grains. In cereals they exist in two forms, one of which is a duplication of the basic structure [ (PUBMED:3667571) ]. Proteins of the Bowman-Birk inhibitor family of serine proteinase inhibitors interact with the enzymes they inhibit via an exposed surface loop that adopts the canonical proteinase inhibitory conformation. The resulting non-covalent complex renders the proteinase inactive. This inhibition mechanism is common for the majority of serine proteinase inhibitor proteins and many analogous examples are known. A particular feature of the Bowman-Birk inhibitor protein, however, is that the interacting loop is a particularly well-defined disulphide-linked short beta-sheet region [ (PUBMED:11375759) (PUBMED:12325158) (PUBMED:12643767) ].
GO component:	extracellular region (GO:0005576)
GO function:	serine-type endopeptidase inhibitor activity (GO:0004867)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 644 BowB domains in 437 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing BowB domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with BowB domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing BowB domain in the selected taxonomic class.

• Structure (3D structures containing this domain)

• 3D Structures of BowB domains in PDB

  PDB code	Main view	Title
  1bbi		THREE-DIMENSIONAL STRUCTURE OF SOYBEAN TRYPSIN(SLASH)CHYMOTRYPSIN BOWMAN-BIRK INHIBITOR IN SOLUTION
  1bi6		NMR STRUCTURE OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM
  1c2a		CRYSTAL STRUCTURE OF BARLEY BBI
  1d6r		CRYSTAL STRUCTURE OF CANCER CHEMOPREVENTIVE BOWMAN-BIRK INHIBITOR IN TERNARY COMPLEX WITH BOVINE TRYPSIN AT 2.3 A RESOLUTION. STRUCTURAL BASIS OF JANUS-FACED SERINE PROTEASE INHIBITOR SPECIFICITY
  1h34		Crystal structure of lima bean trypsin inhibitor
  1k9b		Crystal structure of the bifunctional soybean Bowman-Birk inhibitor at 0.28 nm resolution. Structural peculiarities in a folded protein conformation
  1mvz		NMR solution structure of a Bowman Birk inhibitor isolated from snail medic seeds (Medicago Scutellata)
  1pbi		CRYSTAL STRUCTURE OF A BOWMAN-BIRK INHIBITOR FROM PEA SEEDS
  1pi2		REACTIVE SITES OF AN ANTICARCINOGENIC BOWMAN-BIRK PROTEINASE INHIBITOR ARE SIMILAR TO OTHER TRYPSIN INHIBITORS
  1sbw		CRYSTAL STRUCTURE OF MUNG BEAN INHIBITOR LYSINE ACTIVE FRAGMENT COMPLEX WITH BOVINE BETA-TRYPSIN AT 1.8A RESOLUTION
  1tab		STRUCTURE OF THE TRYPSIN-BINDING DOMAIN OF BOWMAN-BIRK TYPE PROTEASE INHIBITOR AND ITS INTERACTION WITH TRYPSIN
  1tx6		trypsin:BBI complex
  2aih		1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris.
  2bbi		THREE-DIMENSIONAL STRUCTURE OF SOYBEAN TRYPSIN(SLASH)CHYMOTRYPSIN BOWMAN-BIRK INHIBITOR IN SOLUTION
  2bi6		NMR STUDY OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM
  2fj8		High resolution structure of barley Bowman-Birk inhibitor
  2g81		Crystal Structure of the Bowman-Birk Inhibitor from Vigna unguiculata Seeds in Complex with Beta-trypsin at 1.55 Angstrons Resolution
  2iln		Crystal structure of the Bowman-Birk inhibitor from snail medic seeds in complex with bovine trypsin
  2qn5		Crystal Structure and Functional Study of the Bowman-Birk Inhibitor from Rice Bran in Complex with Bovine Trypsin
  2r33		Crystal structure of a Bowman-Birk inhibitor from Vigna unguiculata seeds
  3myw		The Bowman-Birk type inhibitor from mung bean in ternary complex with porcine trypsin
  3ru4		Crystal structure of the Bowman-Birk serine protease inhibitor BTCI in complex with trypsin and chymotrypsin

• Links (links to other resources describing this domain)

• PROSITE	BOWMAN_BIRK
  INTERPRO	IPR000877
  PFAM	Bowman-Birk_leg

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