Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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Agenet Tudor-like domain present in plant sequences.

SMART accession number:	SM00743
Description:	Domain in plant sequences with possible chromatin-associated functions.
Interpro abstract (IPR014002):	This entry represents an agenet domain found in EMSY-like (AtEML) proteins, which have possible roles in chromatin regulation and are related to the BRCA2-interacting human oncoprotein EMSY [ (PUBMED:21830950) ]. Proteins containing this domain also include MRG2 (AT1G02740) from Arabidopsis and PHD finger protein 20-like protein 1 (PHF20L1) from animals. MRG2 binds to the FLOWERING LOCUS T locus and elevates the expression in an H3K36me3-dependent manner [ (PUBMED:25183522) ]. The function of PHF20L1 is not clear.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 8129 Agenet domains in 3554 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing Agenet domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Agenet domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing Agenet domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: chromatin
  

• Structure (3D structures containing this domain)

• 3D Structures of Agenet domains in PDB

  PDB code	Main view	Title
  2equ		Solution structure of the tudor domain of PHD finger protein 20-like 1
  4pl6		4PL6
  4pli		4PLI
  4pll		4PLL

• Links (links to other resources describing this domain)

• INTERPRO	IPR014002

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