Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

• HOME
• SETUP
• FAQ
• ABOUT
• GLOSSARY
• WHAT'S NEW
• FEEDBACK

PIG-X PIG-X / PBN1

SMART accession number:	SM00780
Description:	Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I. These enzymes are involved in the transfer of sugar molecules.
Interpro abstract (IPR013233):	Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I [ (PUBMED:15635094) ]. These enzymes are involved in the transfer of sugar molecules. They probably act by stabilizing the mannosyltransferase PIG-M (GPI14 in yeast) [ (PUBMED:15635094) (PUBMED:16418276) ].
GO process:	GPI anchor biosynthetic process (GO:0006506)
GO component:	endoplasmic reticulum membrane (GO:0005789)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 1054 PIG-X domains in 1054 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing PIG-X domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with PIG-X domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing PIG-X domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 50.00 map00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 50.00 map01031 Glycan structures - biosynthesis 2 This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PIG-X domain which could be assigned to a KEGG orthologous group, and not all proteins containing PIG-X domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Links (links to other resources describing this domain)

• PFAM	PIG-X
  INTERPRO	IPR013233

Send comments to Ivica Letunic