Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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Ad_cyc_g-alpha Adenylate cyclase G-alpha binding domain

SMART accession number:	SM00789
Description:	This fungal domain is found in adenylate cyclase and interacts with the alpha subunit of heterotrimeric G proteins.
Interpro abstract (IPR013716):	Adenylate cyclase catalyses the conversion of ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate. It plays an essential role in the regulation of cellular metabolism by catalysing the synthesis of a second messenger, cAMP. G protein-mediated signalling is implicated in yeast and fungal cAMP pathways. The cAMP-PKA pathway consists of an extracellular ligand-sensitive G protein-coupled receptor, a G protein signal transmitter, and the effector adenylate cyclase. The product of adenylate cyclase, cAMP, acts as an intracellular second messenger [ (PUBMED:16924114) ]. GTP-bound RAS2 is required to elicit magnesium-dependent adenylyl cyclase activity in Saccharomyces cerevisiae. In Schizosaccharomyces pombe, however, the cyclase is probably not regulated by RAS proteins, but is activated by git1. In S. pombe, Gpa2 Galpha binds an N-terminal domain of adenylate cyclase, comprising a moderately conserved sequence, which is within a region that is poorly related to other fungal adenylate cyclases. Adenylate cyclase is directly activated by a fungal G protein, which suggests a distinct activation mechanism from that of mammals [ (PUBMED:15831585) ]. This fungal domain interacts with the alpha subunit of heterotrimeric G proteins [ (PUBMED:15831585) ].
GO process:	cAMP biosynthetic process (GO:0006171)
GO function:	magnesium ion binding (GO:0000287), adenylate cyclase activity (GO:0004016)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 191 Ad_cyc_g-alpha domains in 189 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing Ad_cyc_g-alpha domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Ad_cyc_g-alpha domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing Ad_cyc_g-alpha domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 100.00 map00230 Purine metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with Ad_cyc_g-alpha domain which could be assigned to a KEGG orthologous group, and not all proteins containing Ad_cyc_g-alpha domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Links (links to other resources describing this domain)

• PFAM	Ad_cyc_g-alpha
  INTERPRO	IPR013716

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