Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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Alpha-L-AF_C Alpha-L-arabinofuranosidase C-terminus

SMART accession number:	SM00813
Description:	This entry represents the C terminus (approximately 200 residues) of bacterial and eukaryotic alpha-L-arabinofuranosidase. This catalyses the hydrolysis of non-reducing terminal alpha-L-arabinofuranosidic linkages in L-arabinose-containing polysaccharides.
Interpro abstract (IPR010720):	This entry represents the C terminus (approximately 200 residues) of bacterial and eukaryotic alpha-L-arabinofuranosidase ( EC 3.2.1.55 ). This catalyses the hydrolysis of non-reducing terminal alpha-L-arabinofuranosidic linkages in L-arabinose-containing polysaccharides [ (PUBMED:7887599) ].
GO process:	L-arabinose metabolic process (GO:0046373)
GO function:	alpha-L-arabinofuranosidase activity (GO:0046556)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 9126 Alpha-L-AF_C domains in 9109 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing Alpha-L-AF_C domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Alpha-L-AF_C domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing Alpha-L-AF_C domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 98.31 map00520 Nucleotide sugars metabolism 1.69 map00500 Starch and sucrose metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with Alpha-L-AF_C domain which could be assigned to a KEGG orthologous group, and not all proteins containing Alpha-L-AF_C domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of Alpha-L-AF_C domains in PDB

  PDB code	Main view	Title
  1pz2		Crystal structure of a transient covalent reaction intermediate of a family 51 alpha-L-arabinofuranosidase
  1pz3		Crystal structure of a family 51 (GH51) alpha-L-arabinofuranosidase from Geobacillus stearothermophilus T6
  1qw8		Crystal structure of a family 51 alpha-L-arabinofuranosidase in complex with Ara-alpha(1,3)-Xyl
  1qw9		Crystal structure of a family 51 alpha-L-arabinofuranosidase in complex with 4-nitrophenyl-Ara
  2c7f		The Structure of a family 51 arabinofuranosidase, Araf51, from Clostridium thermocellum in complex with 1,5-alpha-L-Arabinotriose.
  2c8n		The Structure of a family 51 arabinofuranosidase, Araf51, from Clostridium thermocellum in complex with 1,3-linked arabinoside of xylobiose.
  2vrk		Structure of a seleno-methionyl derivative of wild type arabinofuranosidase from Thermobacillus xylanilyticus
  2vrq		Structure of an inactive mutant of arabinofuranosidase from Thermobacillus xylanilyticus in complex with a pentasaccharide
  2y2w		Elucidation of the substrate specificity and protein structure of AbfB, a family 51 alpha-L-arabinofuranosidase from Bifidobacterium longum.
  3s2c		Structure of the thermostable GH51 alpha-L-arabinofuranosidase from Thermotoga petrophila RKU-1
  3ug3		Crystal structure of alpha-L-arabinofuranosidase from Thermotoga maritima ligand free form
  3ug4		Crystal structure of alpha-L-arabinofuranosidase from Thermotoga maritima arabinose complex
  3ug5		Crystal structure of alpha-L-arabinofuranosidase from Thermotoga maritima xylose complex
  4atw		The crystal structure of Arabinofuranosidase

• Links (links to other resources describing this domain)

• INTERPRO	IPR010720
  PFAM	Alpha-L-AF_C

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