Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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PKS_KR

SMART accession number:	SM00822
Description:	This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 38684 PKS_KR domains in 29018 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing PKS_KR domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with PKS_KR domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing PKS_KR domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 9.72 map00632 Benzoate degradation via CoA ligation 8.33 map00350 Tyrosine metabolism 8.33 map00564 Glycerophospholipid metabolism 8.33 map00903 Limonene and pinene degradation 8.33 map00960 Alkaloid biosynthesis II 8.33 map00310 Lysine degradation 8.33 map00624 1- and 2-Methylnaphthalene degradation 8.33 map00360 Phenylalanine metabolism 8.33 map00340 Histidine metabolism 8.33 map00642 Ethylbenzene degradation 5.56 map00061 Fatty acid biosynthesis 4.17 map01053 Biosynthesis of siderophore group nonribosomal peptides 3.47 map01040 Biosynthesis of unsaturated fatty acids 1.39 map00562 Inositol phosphate metabolism 0.69 map04910 Insulin signaling pathway This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PKS_KR domain which could be assigned to a KEGG orthologous group, and not all proteins containing PKS_KR domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of PKS_KR domains in PDB

  PDB code	Main view	Title
  2fr0		The first ketoreductase of the erythromycin synthase (crystal form 1)
  2fr1		The first ketoreductase of the erythromycin synthase (crystal form 2)
  2vz8		Crystal Structure of Mammalian Fatty Acid Synthase
  2vz9		Crystal Structure of Mammalian Fatty Acid Synthase in complex with NADP
  2z5l		The first ketoreductase of the tylosin PKS
  3mjc		Structure of A-type Ketoreductases from Modular Polyketide Synthase
  3mje		Structure of A-type Ketoreductases from Modular Polyketide Synthase
  3mjs		Structure of A-type Ketoreductases from Modular Polyketide Synthase
  3mjt		Structure of A-type Ketoreductases from Modular Polyketide Synthase
  3mjv		Structure of A-type Ketoreductases from Modular Polyketide Synthase
  3slk		Structure of ketoreductase and enoylreductase didomain from modular polyketide synthase
  4dif		Structure of A1-type ketoreductase
  4hxy		PlmKR1-Ketoreductase from the first module of phoslactomycin biosynthesis in Streptomyces sp. HK803
  4imp		The missing linker: a dimerization motif located within polyketide synthase modules
  4j1q		Crystal structure of a ketoreductase domain from the bacillaene assembly line
  4j1s		Crystal structure of a ketoreductase domain from the bacillaene assembly line
  4l4x		An A2-type ketoreductase from a modular polyketide synthase
  4piv		4PIV
  5bp4		5BP4
  5c37		5C37
  5d2e		5D2E
  5ktk		5KTK

• Links (links to other resources describing this domain)

• PFAM	KR domain

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