Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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PKS_ER Enoylreductase

SMART accession number:	SM00829
Description:	Enoylreductase in Polyketide synthases.
Interpro abstract (IPR020843):	Modular polyketide synthases are giant multifunctional enzymes that biosynthesise a variety of secondary metabolites using various combinations of dehydratase (DH), ketoreductase (KR) and enoyl-reductase (ER) domains [ (PUBMED:20666435) ]. This entry represents the enoylreductase domain from a number of polyketide sythases.
GO function:	oxidoreductase activity (GO:0016491)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 10815 PKS_ER domains in 10295 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing PKS_ER domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with PKS_ER domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing PKS_ER domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 11.25 map00061 Fatty acid biosynthesis 10.00 map00632 Benzoate degradation via CoA ligation 7.50 map00350 Tyrosine metabolism 7.50 map00564 Glycerophospholipid metabolism 7.50 map00903 Limonene and pinene degradation 7.50 map00960 Alkaloid biosynthesis II 7.50 map00310 Lysine degradation 7.50 map01040 Biosynthesis of unsaturated fatty acids 7.50 map00624 1- and 2-Methylnaphthalene degradation 7.50 map00360 Phenylalanine metabolism 7.50 map00340 Histidine metabolism 7.50 map00642 Ethylbenzene degradation 2.50 map00562 Inositol phosphate metabolism 1.25 map04910 Insulin signaling pathway This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PKS_ER domain which could be assigned to a KEGG orthologous group, and not all proteins containing PKS_ER domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of PKS_ER domains in PDB

  PDB code	Main view	Title
  2vz8		Crystal Structure of Mammalian Fatty Acid Synthase
  2vz9		Crystal Structure of Mammalian Fatty Acid Synthase in complex with NADP
  3slk		Structure of ketoreductase and enoylreductase didomain from modular polyketide synthase
  4w82		4W82
  4w9n		4W9N
  5bp4		5BP4
  5dov		5DOV
  5doz		5DOZ
  5dp1		5DP1
  5dp2		5DP2

• Links (links to other resources describing this domain)

• INTERPRO	IPR020843

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