Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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PepX_C X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain

SMART accession number:	SM00939
Description:	This domain is found at the C-terminus of cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). The domain, which is a beta sandwich, is also found in serine peptidases belonging to MEROPS peptidase family S15: Xaa-Pro dipeptidyl-peptidases. Members of this entry, that are not characterised as peptidases, show extensive low-level similarity to the Xaa-Pro dipeptidyl-peptidases.
Interpro abstract (IPR013736):	This domain is found at the C terminus of cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). The domain, which is a beta sandwich, is also found in serine peptidases belonging to MEROPS peptidase family S15: Xaa-Pro dipeptidyl-peptidases. Members of this entry, that are not characterised as peptidases, show extensive low-level similarity to the Xaa-Pro dipeptidyl-peptidases.
GO function:	dipeptidyl-peptidase activity (GO:0008239)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 15789 PepX_C domains in 15787 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing PepX_C domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with PepX_C domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing PepX_C domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Structure (3D structures containing this domain)

• 3D Structures of PepX_C domains in PDB

  PDB code	Main view	Title
  1ju3		BACTERIAL COCAINE ESTERASE COMPLEX WITH TRANSITION STATE ANALOG
  1ju4		BACTERIAL COCAINE ESTERASE COMPLEX WITH PRODUCT
  1l7q		Ser117Ala Mutant of Bacterial Cocaine Esterase cocE
  1l7r		Tyr44Phe Mutant of Bacterial Cocaine Esterase cocE
  1lns		Crystal Structure Analysis of the X-Prolyl Dipeptidyl Aminopeptidase From Lactococcus lactis
  1mpx		ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE
  1nx9		Acetobacter turbidans alpha-amino acid ester hydrolase S205A mutant complexed with ampicillin
  1ryy		Acetobacter turbidans alpha-amino acid ester hydrolase Y206A mutant
  2b4k		Acetobacter turbidans alpha-amino acid ester hydrolase complexed with phenylglycine
  2b9v		Acetobacter turbidans alpha-amino acid ester hydrolase
  3i2f		Cocaine Esterase with mutations T172R / G173Q, bound to DTT adduct
  3i2g		Cocaine Esterase with mutation G173Q, bound to DTT adduct
  3i2h		Cocaine Esterase with mutation L169K, bound to DTT adduct
  3i2i		Cocaine Esterase with mutation T172R, bound to DTT adduct
  3i2j		Cocaine Esterase, wild type, without a ligand
  3i2k		Cocaine Esterase, wild type, bound to a DTT adduct
  3ib3		Crystal Structure of SACOL2612 - CocE/NonD family hydrolase from Staphylococcus aureus
  3ida		Thermostable Cocaine Esterase with mutations L169K and G173Q, bound to DTT adduct
  3iii		1.95 Angstrom Crystal Structure of CocE/NonD family hydrolase (SACOL2612) from Staphylococcus aureus
  3puh		Cocaine Esterase, wild-type biologically active dimer
  3pui		Cocaine Esterase with mutations G4C, S10C
  4p08		4P08
  4pf1		4PF1

• Links (links to other resources describing this domain)

• INTERPRO	IPR013736
  PFAM	PepX_C

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