Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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TPK_B1_binding Thiamin pyrophosphokinase, vitamin B1 binding domain

SMART accession number:	SM00983
Description:	Thiamin pyrophosphokinase (TPK) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis (PUBMED:11435118).
Interpro abstract (IPR007373):	Thiamin pyrophosphokinase (TPK, EC 2.7.6.2 ) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [ (PUBMED:11435118) ].
GO process:	thiamine diphosphate biosynthetic process (GO:0009229)
GO function:	thiamine binding (GO:0030975)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 7992 TPK_B1_binding domains in 7991 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing TPK_B1_binding domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with TPK_B1_binding domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing TPK_B1_binding domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Structure (3D structures containing this domain)

• 3D Structures of TPK_B1_binding domains in PDB

  PDB code	Main view	Title
  1ig0		Crystal Structure of yeast Thiamin Pyrophosphokinase
  1ig3		Mouse Thiamin Pyrophosphokinase Complexed with Thiamin
  2f17		Mouse Thiamin Pyrophosphokinase in a Ternary Complex with Pyrithiamin Pyrophosphate and AMP at 2.5 angstrom
  2g9z		Thiamin pyrophosphokinase from Candida albicans
  2hh9		Thiamin pyrophosphokinase from Candida albicans
  3cq9		Crystal structure of the lp_1622 protein from Lactobacillus plantarum. Northeast Structural Genomics Consortium target LpR114
  3ihk		Crystal Structure of thiamin pyrophosphokinase from S.mutans, Northeast Structural Genomics Consortium Target SmR83
  3k94		Crystal Structure of Thiamin pyrophosphokinase from Geobacillus thermodenitrificans, Northeast Structural Genomics Consortium Target GtR2
  3l8m		Crystal Structure of a probable thiamine pyrophosphokinase from Staphylococcus saprophyticus subsp. saprophyticus. Northeast Structural Genomics Consortium target id SyR86
  3lm8		Crystal Structure of Thiamine pyrophosphokinase from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR677
  3mel		Crystal Structure of Thiamin pyrophosphokinase family protein from Enterococcus faecalis, Northeast Structural Genomics Consortium Target EfR150
  3s4y		Crystal structure of human thiamin pyrophosphokinase 1

• Links (links to other resources describing this domain)

• PFAM	TPK_B1_binding
  INTERPRO	IPR007373

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