CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo (PUBMED:10842059). Most members of the family also have a Cactin_mid domain further upstream.
Family alignment:
There are 2979 CactinC_cactus domains in 2978 proteins in SMART's nrdb database.
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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing CactinC_cactus domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with CactinC_cactus domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing CactinC_cactus domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
Cactin, a conserved protein that interacts with the Drosophila IkappaBprotein cactus and modulates its function.
Mech Dev. 2000; 94: 57-65
Display abstract
Rel transcription factors function in flies and vertebrates in immunityand development. Although Rel proteins regulate diverse processes, thecontrol of their function is conserved. In a two-hybrid screen foradditional components of the pathway using the Drosophila I-kappaB proteinCactus as a bait, we isolated a novel coiled-coil protein with N-terminalArg-Asp (RD)- like motifs that we call Cactin. Like the other componentsof this pathway, Cactin is evolutionarily conserved. Over-expression ofcactin in a cactus(A2) heterozygous background results in the enhancementof the cactus phenotype. Both the embryonic lethality and ventralizationare strongly increased, suggesting that cactin functions in the Relpathway controlling the formation of dorsal-ventral embryonic polarity.
Links (links to other resources describing this domain)
