Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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CorC_HlyC Transporter associated domain

SMART accession number:	SM01091
Description:	This small domain is found in a family of proteins with the DUF21 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.
Interpro abstract (IPR005170):	This small domain is found in a family of proteins with the CBS IPR002550 domain and two CBS domains with this domain found at the C terminus of the proteins, the domain is also found at the C terminus of some Na + /H + antiporters [ (PUBMED:20163190) ]. This domain is also found in CorC that is involved in Magnesium and cobalt efflux [ (PUBMED:1779764) ]. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 47479 CorC_HlyC domains in 47479 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing CorC_HlyC domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with CorC_HlyC domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing CorC_HlyC domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: transport
  

• Structure (3D structures containing this domain)

• 3D Structures of CorC_HlyC domains in PDB

  PDB code	Main view	Title
  2nqw		Structure of the transporter associated domain from PG_0272, a CBS domain protein from Porphyromonas gingivalis
  2o3g		Structural Genomics, the crystal structure of a conserved putative domain from Neisseria meningitidis MC58
  2oai		The structure of transporter associated domain CorC_HlyC from a Xylella fastidiosa Temecula1 hemolysin.
  2p13		Transporter associated domain CorC_HlyC from Nitrosomonas europaea
  2p3h		Crystal structure of the CorC_HlyC domain of a putative Corynebacterium glutamicum hemolysin
  2p4p		Crystal structure of a CorC_HlyC domain from Haemophilus ducreyi
  2pli		Crystal structure of putative Mg2+ and Co2+ transporter(CorC)associated region from Neisseria meningitidis MC58
  2pls		Structural Genomics, the crystal structure of the CorC/HlyC transporter associated domain of a CBS domain protein from Chlorobium tepidum TLS
  2r2z		The crystal structure of a hemolysin domain from Enterococcus faecalis V583
  2r8d		The structure of transporter associated domain CorC_HlyC from a Xylella fastidiosa Temecula1 hemolysin in complex with Mg++ and Mn++
  2rk5		Crystal structure of a domain of the putative hemolysin from Streptococcus mutans UA159
  3ded		C-terminal domain of Probable hemolysin from Chromobacterium violaceum
  3lae		The crystal structure of a functionally unknown conserved protein from Haemophilus influenzae Rd KW20
  3llb		The crystal structure of the protein PA3983 with unknown function from Pseudomonas aeruginosa PAO1
  4hg0		Crystal Structure of magnesium and cobalt efflux protein CorC, Northeast Structural Genomics Consortium (NESG) Target ER40

• Links (links to other resources describing this domain)

• INTERPRO	IPR005170
  PFAM	CorC_HlyC

Send comments to Ivica Letunic