Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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CO_deh_flav_C CO dehydrogenase flavoprotein C-terminal domain

SMART accession number:	SM01092
Description:	-
Interpro abstract (IPR005107):	Proteins containing this domain form structural complexes with other known families, such as IPR008274 and IPR001041 . The carbon monoxide (CO) dehydrogenase of Oligotropha carboxidovorans is a heterotrimeric complex composed of a apoflavoprotein, a molybdoprotein, and an iron-sulphur protein. It can be dissociated with sodium dodecylsulphate [ (PUBMED:10636886) ]. CO dehydrogenase catalyzes the oxidation of CO according to the following equation [ (PUBMED:11076018) ]: CO + H2O = CO2 + 2e + 2H+ Subunit S represents the iron-sulphur protein of CO dehydrogenase and is clearly divided into a C- and an N-terminal domain, each binding a [2Fe-2S] cluster [ (PUBMED:10430865) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 28996 CO_deh_flav_C domains in 28937 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing CO_deh_flav_C domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with CO_deh_flav_C domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing CO_deh_flav_C domain in the selected taxonomic class.

• Structure (3D structures containing this domain)

• 3D Structures of CO_deh_flav_C domains in PDB

  PDB code	Main view	Title
  1ffu		CARBON MONOXIDE DEHYDROGENASE FROM HYDROGENOPHAGA PSEUDOFLAVA WHICH LACKS THE MO-PYRANOPTERIN MOIETY OF THE MOLYBDENUM COFACTOR
  1ffv		CARBON MONOXIDE DEHYDROGENASE FROM HYDROGENOPHAGA PSEUDOFLAVA
  1fiq		CRYSTAL STRUCTURE OF XANTHINE OXIDASE FROM BOVINE MILK
  1fo4		CRYSTAL STRUCTURE OF XANTHINE DEHYDROGENASE ISOLATED FROM BOVINE MILK
  1jro		Crystal Structure of Xanthine Dehydrogenase from Rhodobacter capsulatus
  1jrp		Crystal Structure of Xanthine Dehydrogenase inhibited by alloxanthine from Rhodobacter capsulatus
  1n5w		Crystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Oxidized form
  1n5x		Xanthine Dehydrogenase from Bovine Milk with Inhibitor TEI-6720 Bound
  1n60		Crystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Cyanide-inactivated Form
  1n61		Crystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Dithionite reduced state
  1n62		Crystal Structure of the Mo,Cu-CO Dehydrogenase (CODH), n-butylisocyanide-bound state
  1n63		Crystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Carbon monoxide reduced state
  1rm6		Structure of 4-hydroxybenzoyl-CoA reductase from Thauera aromatica
  1sb3		Structure of 4-hydroxybenzoyl-CoA reductase from Thauera aromatica
  1t3q		Crystal structure of quinoline 2-Oxidoreductase from Pseudomonas Putida 86
  1v97		Crystal Structure of Bovine Milk Xanthine Dehydrogenase FYX-051 bound form
  1vdv		Bovine Milk Xanthine Dehydrogenase Y-700 Bound Form
  1wyg		Crystal Structure of a Rat Xanthine Dehydrogenase Triple Mutant (C535A, C992R and C1324S)
  1zxi		Reconstituted CO dehydrogenase from Oligotropha carboxidovorans
  2ckj		Human milk xanthine oxidoreductase
  2e1q		Crystal Structure of Human Xanthine Oxidoreductase mutant, Glu803Val
  2e3t		Crystal structure of rat xanthine oxidoreductase mutant (W335A and F336L)
  2w3r		Crystal Structure of Xanthine Dehydrogenase (desulfo form) from Rhodobacter capsulatus in complex with hypoxanthine
  2w3s		Crystal Structure of Xanthine Dehydrogenase (desulfo form) from Rhodobacter capsulatus in Complex with Xanthine
  2w54		Crystal Structure of Xanthine Dehydrogenase from Rhodobacter capsulatus in Complex with Bound Inhibitor Pterin-6-aldehyde
  2w55		Crystal Structure of Xanthine Dehydrogenase (E232Q variant) from Rhodobacter capsulatus in Complex with Hypoxanthine
  3am9		Complex of bovine xanthine dehydrogenase and trihydroxy FYX-051
  3amz		Bovine Xanthine Oxidoreductase urate bound form
  3an1		Crystal structure of rat D428A mutant, urate bound form
  3ax7		Bovine Xanthine Oxidase, protease cleaved form
  3ax9		Bovine xanthine oxidase, protease cleaved form
  3b9j		Structure of Xanthine Oxidase with 2-hydroxy-6-methylpurine
  3bdj		Crystal Structure of Bovine Milk Xanthine Dehydrogenase with a Covalently Bound Oxipurinol Inhibitor
  3etr		Crystal structure of xanthine oxidase in complex with lumazine
  3eub		Crystal Structure of Desulfo-Xanthine Oxidase with Xanthine
  3hrd		Crystal structure of nicotinate dehydrogenase
  3nrz		Crystal Structure of Bovine Xanthine Oxidase in Complex with Hypoxanthine
  3ns1		Crystal Structure of Bovine Xanthine Oxidase in Complex with 6-Mercaptopurine
  3nvv		Crystal Structure of Bovine Xanthine Oxidase in Complex with Arsenite
  3nvw		Crystal Structure of Bovine Xanthine Oxidase in Complex with Guanine
  3nvy		Crystal Structure of Bovine Xanthine Oxidase in Complex with Quercetin
  3nvz		Crystal Structure of Bovine Xanthine Oxidase in Complex with Indole-3-Aldehyde
  3sr6		Crystal Structure of Reduced Bovine Xanthine Oxidase in Complex with Arsenite
  3una		Crystal Structure of Bovine Milk Xanthine Dehydrogenase with NAD Bound
  3unc		Crystal Structure of Bovine Milk Xanthine Dehydrogenase to 1.65A Resolution
  3uni		Crystal Structure of Bovine Milk Xanthine Dehydrogenase with NADH Bound
  3zyv		Crystal structure of the mouse liver Aldehyde Oxidase 3 (mAOX3)
  4uhw		4UHW
  4uhx		4UHX
  4yrw		4YRW
  4ysw		4YSW
  4yty		4YTY
  4ytz		4YTZ
  4zoh		4ZOH
  5epg		5EPG
  5g5g		5G5G
  5g5h		5G5H

• Links (links to other resources describing this domain)

• PFAM	CO_deh_flav_C
  INTERPRO	IPR005107

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