Aspzincin_M35

Lysine-specific metallo-endopeptidase
Aspzincin_M35
SMART accession number:SM01351
Description: This is the catalytic region of aspzincins, a group of lysine-specific metallo-endopeptidases in the M35 family. They exhibit the following active-site architecture. The active site is composed of two helices and a loop region and includes the HExxH and GTxDxxYG motifs. In UniProt:P81054 His117, His121 and Asp130 coordinate to the catalytic zinc ligands. An electrostatically negative region composed of Asp154 and Glu157 attracts a positively charged Lys side chain of a substrate in a specific manner (PMID:11679721).
Interpro abstract (IPR029463):

This is the catalytic domain of aspzincins, a group of lysine-specific metallo-endopeptidases in the MEROPS M35 family. They exhibit the following active-site architecture: the active site is composed of two helices and a loop region and includes the HExxH and GTxDxxYG motifs. In protein P81054, His117, His121 and Asp130 coordinate to the catalytic zinc ligands. An electrostatically negative region composed of Asp154 and Glu157 attracts a positively charged Lys side chain of a substrate in a specific manner [(PUBMED:11223512)].

GO function:metalloendopeptidase activity (GO:0004222)
Family alignment:
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There are 911 Aspzincin_M35 domains in 911 proteins in SMART's nrdb database.

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