BC10

Bladder cancer-related protein BC10
BC10
SMART accession number:SM01396
Description: This family consists of a series of short proteins of around 90 residues in length. The human protein O60629 or BC10 has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs) PMID:11920613. The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript. All the editing sites are found in either the 5-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues PMID:15797904. The function of this family is unknown.
Interpro abstract (IPR009598):

This family consists of a series of short proteins of around 90 residues in length. The human protein O60629 (or BC10) has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs) [(PUBMED:15797904)]. The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript. All the editing sites are found in either the 5'-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues [(PUBMED:11920613)]. The function of this family is unknown.

Family alignment:
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There are 0 BC10 domains in 0 proteins in SMART's nrdb database.

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