Granulocyte-macrophage colony-simulating factor (GM-CSF)
SMART accession number:SM00040
Description: GM-CSF stimulates the development of and the cytotoxic activity of white blood cells.
Interpro abstract (IPR000773): Granulocyte-macrophage colony-stimulating factor (GMCSF) is a cytokine that acts in hematopoiesis to stimulate growth and differentiation of hematopoietic precursor cells from various lineages including granulocytes, macrophages, eosinophils and erythrocytes [(PUBMED:2458827), (PUBMED:1569568)]. GMCSF is a glycoprotein of ~120 residues that contains 4 conserved cysteines that participate in disulphide bond formation. The crystal structure of recombinant human GMCSF has been determined [(PUBMED:1569568)]. There are two molecules in the asymmetric unit, which are related by an approximate non-crystallographic 2-fold axis. The overall structure, which is highly compact and globular with a predominantly hydrophobic core, is characterised by a 4-alpha-helix bundle. The helices are arranged in a left-handed anti-parallel fashion, with two overhand connections. Within the connections is a two-stranded anti-parallel beta-sheet. The tertiary structure has a topology similar to that of Sus scrofa (pig) growth factor and interferon-beta. Most of the proposed critical regions for receptor binding are located on a continuous surface at one end of the molecule that includes the C terminus [(PUBMED:1569568)].
GO process:immune response (GO:0006955)
GO component:extracellular region (GO:0005576)
GO function:growth factor activity (GO:0008083), granulocyte macrophage colony-stimulating factor receptor binding (GO:0005129)
Family alignment:
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There are 76 CSF2 domains in 76 proteins in SMART's nrdb database.

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