DHDPSDihydrodipicolinate synthetase family |
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| SMART accession number: | SM01130 |
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| Description: | This family has a TIM barrel structure. This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. |
| Family alignment: |
There are 4005 DHDPS domains in 4005 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes - Cellular role (predicted cellular role)
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Cellular role: metabolism
- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Izard T, Lawrence MC, Malby RL, Lilley GG, Colman PM
- The three-dimensional structure of N-acetylneuraminate lyase from Escherichiacoli.
- Structure. 1994; 2: 361-9
- Display abstract
BACKGROUND: N-acetylneuraminate lyase catalyzes the cleavage ofN-acetylneuraminic acid (sialic acid) to form pyruvate andN-acetyl-D-mannosamine. The enzyme plays an important role in the regulation ofsialic acid metabolism in bacteria. The reverse reaction can be exploited for thesynthesis of sialic acid and some of its derivatives. RESULTS: The structure ofthe enzyme from Escherichia coli has been determined to 2.2 A resolution by X-raycrystallography. The enzyme is shown to be a tetramer, in which each subunitconsists of an alpha/beta-barrel domain followed by a carboxy-terminal extension of three alpha-helices. CONCLUSIONS: The active site of the enzyme is tentativelyidentified as a pocket at the carboxy-terminal end of the eight-strandedbeta-barrel. Lys165 lies within this pocket and is probably the reactive residue which forms a Schiff base intermediate with the substrate. The sequence ofN-acetylneuraminate lyase has similarities to those of dihydrodipicolinatesynthase and MosA (an enzyme implicated in rhizopine synthesis) suggesting thatthese last two enzymes share a similar structure to N-acetylneuraminate lyase.
- Structure (3D structures containing this domain)
3D Structures of DHDPS domains in PDB
PDB code Main view Title 1dhp 
Dihydrodipicolinate synthase 1f5z 
Crystal structure analysis of n-acetylneuraminate lyase from haemophilus influenzae: crystal form i 1f6k 
Crystal structure analysis of n-acetylneuraminate lyase from haemophilus influenzae: crystal form ii 1f6p 
Crystal structure analysis of n-acetylneuraminate lyase from haemophilus influenzae: crystal form iii 1f73 
Crystal structure analysis of n-acetylneuraminate lyase from haemophilus influenzae: crystal form iii in complex with sialic acid alditol 1f74 
Crystal structure analysis of n-acetylneuraminate lyase from haemophilus influenzae: crystal form ii complexed with 4-deoxy-sialic acid 1f7b 
Crystal structure analysis of n-acetylneuraminate lyase from haemophilus influenzae: crystal form ii in complex with 4-oxo-sialic acid 1fdy 
N-acetylneuraminate lyase in complex with hydroxypyruvate 1fdz 
N-acetylneuraminate lyase in complex with pyruvate via borohydride reduction 1hl2 
Crystal structure of n-acetylneuraminate lyase from e. coli mutant l142r in complex with b-hydroxypyruvate 1nal 
The three-dimensional structure of n-acetylneuraminate lyase from escherichia coli 1o5k 
Crystal structure of dihydrodipicolinate synthase (tm1521) from thermotoga maritima at 1.80 a resolution 1s5t 
Crystal structure analysis of a mutant of dihydrodipicolinate synthase--residue thr44 to val44 1s5v 
Crystal structure analysis of a mutant of dihydrodipicolinate synthase--residue tyr107 to phe107 1s5w 
Crystal structure analysis of a mutant of dihydrodipicolinate synthase--residue tyr133 to phe133 1w37 
2-keto-3-deoxygluconate(kdg) aldolase of sulfolobus solfataricus 1w3i 
Sulfolobus solfataricus 2-keto-3-deoxygluconate (kdg) aldolase complex with pyruvate 1w3n 
Sulfolobus solfataricus 2-keto-3-deoxygluconate (kdg) aldolase complex with d-kdg 1w3t 
Sulfolobus solfataricus 2-keto-3-deoxygluconate (kdg) aldolase complex with d-kdgal, d-glyceraldehyde and pyruvate 1xky 
Crystal structure of dihydrodipicolinate synthase dapa-2 (ba3935) from bacillus anthracis at 1.94a resolution. 1xl9 
Crystal structure of dihydrodipicolinate synthase dapa-2 (ba3935) from bacillus anthracis. 1xxx 
Crystal structure of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosis 1yxc 
Structure of e. coli dihydrodipicolinate synthase to 1.9 a 1yxd 
Structure of e. coli dihydrodipicolinate synthase bound with allosteric inhibitor (s)-lysine to 2.0 a 2a6l 
Dihydrodipicolinate synthase (e. coli)- mutant r138h 2a6n 
Dihydrodipicolinate synthase (e. coli)- mutant r138a 2ats 
Dihydrodipicolinate synthase co-crystallised with (s)-lysine 2ehh 
Crystal structure of dihydrodipicolinate synthase from aquifex aeolicus 2hmc 
The crystal structure of dihydrodipicolinate synthase dapa from agrobacterium tumefaciens 2nuw 
2-keto-3-deoxygluconate aldolase from sulfolobus acidocaldarius, native structure at 1.8 a resolution 2nux 
2-keto-3-deoxygluconate aldolase from sulfolobus acidocaldarius, native structure in p6522 at 2.5 a resolution 2nuy 
2-keto-3-deoxygluconate aldolase from sulfolobus acidocaldarius in complex with pyruvate 2ojp 
The crystal structure of a dimeric mutant of dihydrodipicolinate synthase from e.coli- dhdps-l197y 2pcq 
Crystal structure of putative dihidrodipicolinate synthase (ttha0737) from thermus thermophilus hb8 2pur 
Structure of dihydrodipicolinate synthase mutant thr44ser at 1.7 a. 2r8w 
The crystal structure of dihydrodipicolinate synthase (atu0899) from agrobacterium tumefaciens str. c58 2r91 
Crystal structure of kd(p)ga from t.tenax 2r94 
Crystal structure of kd(p)ga from t.tenax 2rfg 
Crystal structure of dihydrodipicolinate synthase from hahella chejuensis at 1.5a resolution 2v8z 
Crystal structure of yage, a prophage protein belonging to the dihydrodipicolinic acid synthase family from e. coli k12 2v9d 
Crystal structure of yage, a prophage protein belonging to the dihydrodipicolinic acid synthase family from e. coli k12 2vc6 
Structure of mosa from s. meliloti with pyruvate bound 2yxg 
Crystal structure of dihyrodipicolinate synthase (dapa) 3b4u 
Crystal structure of dihydrodipicolinate synthase from agrobacterium tumefaciens str. c58 3c0j 
Structure of e. coli dihydrodipicolinate synthase complexed with hydroxypyruvate 3cpr 
The crystal structure of corynebacterium glutamicum dihydrodipicolinate synthase to 2.2 a resolution 3d0c 
Crystal structure of dihydrodipicolinate synthase from oceanobacillus iheyensis at 1.9 a resolution 3daq 
Crystal structure of dihydrodipicolinate synthase from methicillin-resistant staphylococcus aureus 3den 
Structure of e. coli dhdps mutant y107w 3di0 
Crystal structure of dihydrodipicolinate synthase from staphylococcus aureus 3di1 
Crystal structure of the staphylococcus aureus dihydrodipicolinate synthase-pyruvate complex 3du0 
E. coli dihydrodipicolinate synthase with first substrate, pyruvate, bound in active site 3dz1 
Crystal structure of dihydrodipicolinate synthase from rhodopseudomonas palustris at 1.87a resolution 3e96 
Crystal structure of dihydrodipicolinate synthase from bacillus clausii 3eb2 
Crystal structure of dihydrodipicolinate synthase from rhodopseudomonas palustris at 2.0a resolution 3flu 
Crystal structure of dihydrodipicolinate synthase from the pathogen neisseria meningitidis 3g0s 
Dihydrodipicolinate synthase from salmonella typhimurium lt2 3hij 
Crystal structure of dihydrodipicolinate synthase from bacillus anthracis in complex with its substrate, pyruvate 3ird 
Structure of dihydrodipicolinate synthase from clostridium botulinum - Links (links to other resources describing this domain)
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PFAM DHDPS