Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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DIL

SMART accession number:	SM01132
Description:	The DIL domain has no known function.
Interpro abstract (IPR002710):	The myosin superfamily consists of at least 15 distinct classes of presumed actin-based molecular motors. All members of the superfamily share a similar motor domain and a tail portion which is diagnostic of the class [ (PUBMED:11212352) ]. Class V myosins are actin-based molecular motors that function in relatively long-range movements of many intracellular cargoes including organelles, membrane vesicles, and mRNA [ (PUBMED:10931864) ]. These motors are ubiquitously found in all eukaryotes. Class V myosins are characterised by the presence of a conserved globular domain at the C terminus of the tail portion: the dilute domain [ (PUBMED:7667878) ]. Myosin V moves via attachment of its amino terminal head (motor) domain to actin cables; its carboxyl terminal dilute domain anchors it to cargoes via attachments to organelle-specific receptors [ (PUBMED:10931864) (PUBMED:15684027) ]. The dilute domain is also found in the afadin family. Afadins are nectin and actin filament-binding proteins that connect nectin to the actin cytoskeleton [ (PUBMED:12456712) ]. The dilute domain of afadin appears to be responsible for actin stress fibre formation [ (PUBMED:25712270) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 6872 DIL domains in 6863 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing DIL domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with DIL domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing DIL domain in the selected taxonomic class.

• Structure (3D structures containing this domain)

• 3D Structures of DIL domains in PDB

  PDB code	Main view	Title
  2f6h		Myosin V cargo binding domain
  3mmi		Crystal structure of the globular tail of Myo4p
  3wb8		Crystal Structure of MyoVa-GTD
  4j5l		Structure of the Cargo Binding Domain from Human Myosin Va
  4j5m		Structure of the Cargo Binding Domain from Human Myosin Vb
  4kp3		Crystal Structure of MyoVa-GTD in Complex with Two Cargos
  4l8t		Structure of the Cargo Binding Domain from Human Myosin Vc
  4ll6		Structure of Myo4p globular tail domain.
  4ll8		Complex of carboxy terminal domain of Myo4p and She3p middle fragment
  4lli		Crystal Structure of human Myosin 5a globular domain
  4lnz		Crystal structure of human Myosin 5b globular domain
  4lwz		Crystal structure of Myo5b globular tail domain in complex with inactive Rab11a
  4lx0		Crystal structure of Myo5b globular tail domain in complex with active Rab11a
  4lx1		Crystal structure of Myo5a globular tail domain
  4lx2		Crystal structure of Myo5a globular tail domain in complex with melanophilin GTBD
  5jcy		5JCY
  5jcz		5JCZ

• Links (links to other resources describing this domain)

• PFAM	DIL
  INTERPRO	IPR002710

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