DUF1899

DUF1899
SMART accession number:SM01166
Description: This set of domains is found in various eukaryotic proteins. Function is unknown.
Interpro abstract (IPR015048):

Coronins are evoluntionarily conserved proteins, mainly involved in actin cytoskeleton organisation. Typically Coronins contain a DUF1899 domain, a series of WD40 repeats, a DUF1900 domain (IPR015049) and a C-terminal coiled-coil domain [(PUBMED:18925370)].

This entry represents the N-terminal DUF1899 domain. A putative actin binding site just downstream of a phosphoserine modification site is proposed to be located in this domain [(PUBMED:12673016), (PUBMED:16027158), (PUBMED:18925370)].

Proteins with this domain include most of the Coronin homologues (besides Coronin 7 [(PUBMED:18925371)]) and Villidin from Dictyostelium discoideum.

Family alignment:
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There are 4857 DUF1899 domains in 4244 proteins in SMART's nrdb database.

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