ELK

ELK
SMART accession number:SM01188
Description: This domain is required for the nuclear localisation of these proteins (PUBMED:11352458). All of these proteins are members of the Tale/Knox homeodomain family, a subfamily within homeobox SM00389.
Interpro abstract (IPR005539):

Homeobox genes, which encode homeodomain (HD) transcription factors, are known to be key regulators of both plant and animal development. In plants homeobox genes are divided into several groups by sequences, one of which is the KNOX (for knotted1-type homeobox) family. Proteins of this family share other conserved domains, the KNOX domain and ELK domain, which is immediately upstream of the HD. The ELK domain spans ~21 amino acids and was dubbed for a highly conserved series of Glu, Leu, and Lys amino acids. It could function as a nuclear localization signal. The ELK domain also is considered to act as a protein-protein interaction domain, but the precise role of this domain has not been determined [(PUBMED:7866030), (PUBMED:10449577), (PUBMED:11549765), (PUBMED:12034492)].

The ELK domain contains repeating hydrophobic residues and has been predicted to form an amphipathic helix [(PUBMED:7866030)].

GO function:DNA binding (GO:0003677)
Family alignment:
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There are 4753 ELK domains in 2255 proteins in SMART's nrdb database.

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