Acidic and basic fibroblast growth factor family.
SMART accession number:SM00442
Description: Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and have neurotrophic activities.
Interpro abstract (IPR002348): The interleukin-1 (IL1) and heparin-binding growth factor (HBGF) families share low sequence similarity (about 25% [(PUBMED:1849658)]) but have very similar structures. Coupled with the Kunitz-type soybean trypsin inhibitors (STI), they form a structural superfamily. Despite their structural correspondence, however, they show no sequence similarity to the STI family. The crystal structures of interleukin-1 beta and HBGF1 have been solved, showing both families to have the same 12-stranded beta-sheet structure [(PUBMED:1738162)]; the beta-sheets are arranged in 3 similar lobes around a central axis, 6 strands forming an anti-parallel beta-barrel [(PUBMED:1707542), (PUBMED:4071057)]. The beta-sheets are generally well preserved and the crystal structures superimpose in these areas. The intervening loops are less well conserved - the loop between beta-strands 6 and 7 is slightly longer in interleukin-1 beta.
GO function:growth factor activity (GO:0008083)
Family alignment:
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There are 772 FGF domains in 772 proteins in SMART's nrdb database.

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