SMART: HATPase_c domain annotation

HATPase_c Histidine kinase-like ATPases

SMART accession number:	SM00387
Description:	Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Interpro abstract (IPR003594):	This domain is found in several ATP-binding proteins, including: histidine kinase [ (PUBMED:15157101) ], DNA gyrase B, topoisomerases [ (PUBMED:15105144) ], heat shock protein HSP90 [ (PUBMED:15292259) (PUBMED:14718169) (PUBMED:15217611) ], phytochrome-like ATPases and DNA mismatch repair proteins. The fold of this domain consists of two layers, alpha/beta, which contains an 8-stranded mixed beta-sheet.
Family alignment:	View or

There are 925732 HATPase_c domains in 922402 proteins in SMART's nrdb database.

Click on the following links for more information.

Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing HATPase_c domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with HATPase_c domain is also avaliable.

Click on the protein counts, or double click on taxonomic names to display all proteins containing HATPase_c domain in the selected taxonomic class.
Cellular role (predicted cellular role)
Cellular role: signalling
Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

3D Structures of HATPase_c domains in PDB

PDB code	Main view	Title
1a4h		STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE IN COMPLEX WITH GELDANAMYCIN
1ah6		STRUCTURE OF THE TETRAGONAL FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
1ah8		STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
1aj6		NOVOBIOCIN-RESISTANT MUTANT (R136H) OF THE N-TERMINAL 24 KDA FRAGMENT OF DNA GYRASE B COMPLEXED WITH NOVOBIOCIN AT 2.3 ANGSTROMS RESOLUTION
1am1		ATP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE
1amw		ADP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE
1b3q		CRYSTAL STRUCTURE OF CHEA-289, A SIGNAL TRANSDUCING HISTIDINE KINASE
1b62		MUTL COMPLEXED WITH ADP
1b63		MUTL COMPLEXED WITH ADPNP
1bgq		RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
1bkn		CRYSTAL STRUCTURE OF AN N-TERMINAL 40KD FRAGMENT OF E. COLI DNA MISMATCH REPAIR PROTEIN MUTL
1bxd		NMR STRUCTURE OF THE HISTIDINE KINASE DOMAIN OF THE E. COLI OSMOSENSOR ENVZ
1byq		HSP90 N-TERMINAL DOMAIN BOUND TO ADP-MG
1ea6		N-terminal 40kDa fragment of NhPMS2 complexed with ADP
1ei1		DIMERIZATION OF E. COLI DNA GYRASE B PROVIDES A STRUCTURAL MECHANISM FOR ACTIVATING THE ATPASE CATALYTIC CENTER
1gjv		Branched-chain alpha-ketoacid dehydrogenase kinase (BCK) complxed with ATP-gamma-S
1gkx		Branched-chain alpha-ketoacid dehydrogenase kinase (BCK)
1gkz		Branched-chain alpha-ketoacid dehydrogenase kinase (BCK) complxed with ADP
1h7s		N-terminal 40kDa fragment of human PMS2
1h7u		NhPMS2-ATPgS
1i58		STRUCTURE OF THE HISTIDINE KINASE CHEA ATP-BINDING DOMAIN IN COMPLEX WITH ATP ANALOG ADPCP AND MAGNESIUM
1i59		STRUCTURE OF THE HISTIDINE KINASE CHEA ATP-BINDING DOMAIN IN COMPLEX WITH ADPNP AND MAGENSIUM
1i5a		STRUCTURE OF CHEA DOMAIN P4 IN COMPLEX WITH ADPCP AND MANGANESE
1i5b		STRUCTURE OF CHEA DOMAIN P4 IN COMPLEX WITH ADPNP AND MANGANESE
1i5c		STRUCTURE OF CHEA DOMAIN P4 IN COMPLEX WITH ADP
1i5d		STRUCTURE OF CHEA DOMAIN P4 IN COMPLEX WITH TNP-ATP
1id0		CRYSTAL STRUCTURE OF THE NUCLEOTIDE BOND CONFORMATION OF PHOQ KINASE DOMAIN
1jm6		Pyruvate dehydrogenase kinase, isozyme 2, containing ADP
1kij		Crystal structure of the 43K ATPase domain of Thermus thermophilus gyrase B in complex with novobiocin
1kzn		Crystal Structure of E. coli 24kDa Domain in Complex with Clorobiocin
1l0o		Crystal Structure of the Bacillus stearothermophilus Anti-Sigma Factor SpoIIAB with the Sporulation Sigma Factor SigmaF
1mu5		Structure of topoisomerase subunit
1mx0		Structure of topoisomerase subunit
1nhh		Crystal structure of N-terminal 40KD MutL protein (LN40) complex with ADPnP and one Rubidium
1nhi		Crystal structure of N-terminal 40KD MutL (LN40) complex with ADPnP and one potassium
1nhj		Crystal structure of N-terminal 40KD MutL/A100P mutant protein complex with ADPnP and one sodium
1osf		Human Hsp90 in complex with 17-desmethoxy-17-N,N-Dimethylaminoethylamino-Geldanamycin
1pvg		Crystal Structure of the ATPase region of Saccharomyces Cerevisiae topoisomerase II
1qy5		Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with the specific ligand NECA
1qy8		Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with Radicicol
1qye		Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with 2-chlorodideoxyadenosine
1qzr		CRYSTAL STRUCTURE OF THE ATPASE REGION OF SACCHAROMYCES CEREVISIAE TOPOISOMERASE II BOUND TO ICRF-187 (DEXRAZOXANE)
1r62		Crystal structure of the C-terminal Domain of the Two-Component System Transmitter Protein NRII (NtrB)
1s14		Crystal structure of Escherichia coli Topoisomerase IV ParE 24kDa subunit
1s16		Crystal Structure of E. coli Topoisomerase IV ParE 43kDa subunit complexed with ADPNP
1tbw		Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation
1tc0		Ligand Induced Conformational Shifts in the N-terminal Domain of GRP94, Open Conformation Complexed with the physiological partner ATP
1tc6		Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation ADP-Complex
1th8		Crystal Structures of the ADP and ATP bound forms of the Bacillus Anti-sigma factor SpoIIAB in complex with the Anti-anti-sigma SpoIIAA: inhibitory complex with ADP, crystal form II
1thn		Crystal Structures of the ADP and ATP bound forms of the Bacillus Anti-sigma factor SpoIIAB in complex with the Anti-anti-sigma SpoIIAA: inhibitory complex with ADP, crystal form I
1tid		Crystal Structures of the ADP and ATP bound forms of the Bacillus Anti-sigma factor SpoIIAB in complex with the Anti-anti-sigma SpoIIAA: Poised for phosphorylation complex with ATP, crystal form I
1til		Crystal Structures of the ADP and ATP bound forms of the Bacillus Anti-sigma factor SpoIIAB in complex with the Anti-anti-sigma SpoIIAA:Poised for phosphorylation complex with ATP, crystal form II
1u0y		N-Domain Of Grp94, with the Charged Domain, In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine
1u0z		N-Domain Of Grp94 Lacking The Charged Domain In Complex With Radicicol
1u2o		Crystal Structure Of The N-Domain Of Grp94 Lacking The Charged Domain In Complex With Neca
1us7		Complex of Hsp90 and P50
1uy6		Human Hsp90-alpha with 9-Butyl-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine
1uy7		Human Hsp90-alpha with 9-Butyl-8-(4-methoxy-benzyl)-9H-purin-6-ylamine
1uy8		Human Hsp90-alpha with 9-Butyl-8-(3-trimethoxy-benzyl)-9H-purin-6ylamine
1uy9		Human Hsp90-alpha with 8-Benzo[1,3]dioxol-,5-ylmethyl-9-butyl-9H-purin-6-ylamine
1uyc		Human Hsp90-alpha with 9-Butyl-8-(2,5-dimethoxy-benzyl)-9H-purin-6-ylamine
1uyd		Human Hsp90-alpha with 9-Butyl-8-(2-chloro-3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine
1uye		Human Hsp90-alpha with 8-(2-chloro-3,4,5-trimethoxy-benzyl)-9-pent-4-ylnyl-9H-purin-6-ylamine
1uyf		Human Hsp90-alpha with 8-(2-chloro-3,4,5-trimethoxy-benzyl)-2-fluoro-9-pent-4-ylnyl-9H-purin-6-ylamine
1uyg		Human Hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9H-purin-6-ylamine
1uyh		Human Hsp90-alpha with 9-Butyl-8-(2,5-dimethoxy-benzyl)-2-fluoro-9H-purin-6-ylamine
1uyi		Human Hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9-pent-9H-purin-6-ylamine
1uyk		Human Hsp90-alpha with 8-Benzo[1,3]dioxol-,5-ylmethyl-9-butyl-2-fluoro-9H-purin-6-ylamine
1uyl		Structure-Activity Relationships in purine-based inhibitor binding to HSP90 isoforms
1uym		Human Hsp90-beta with PU3 (9-Butyl-8(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine)
1y4s		Conformation rearrangement of heat shock protein 90 upon ADP binding
1y4u		Conformation rearrangement of heat shock protein 90 upon ADP binding
1y8n		Crystal structure of the PDK3-L2 complex
1y8o		Crystal structure of the PDK3-L2 complex
1y8p		Crystal structure of the PDK3-L2 complex
1yc1		Crystal Structures of human HSP90alpha complexed with dihydroxyphenylpyrazoles
1yc3		Crystal Structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles
1yc4		Crystal structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles
1yer		HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "CLOSED" CONFORMATION
1yes		HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "OPEN" CONFORMATION
1yet		GELDANAMYCIN BOUND TO THE HSP90 GELDANAMYCIN-BINDING DOMAIN
1ys3		Crystal Structure of the ATP binding domain of PrrB from Mycobacterium Tuberculosis
1ysr		Crystal Structure of ATP binding domain of PrrB from Mycobacterium Tuberculosis
1ysz		Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH NECA
1yt0		Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH ADP
1yt1		Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL
1yt2		Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N APO CRYSTAL
1z59		Topoisomerase VI-B, ADP-bound monomer form
1z5a		Topoisomerase VI-B, ADP-bound dimer form
1z5b		Topoisomerase VI-B, ADP AlF4- bound dimer form
1z5c		Topoisomerase VI-B, ADP Pi bound dimer form
1zw9		Yeast HSP82 in complex with the Novel HSP90 Inhibitor 8-(6-Bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)-adenine
1zwh		Yeast Hsp82 in complex with the novel Hsp90 inhibitor Radester amine
1zxm		Human Topo IIa ATPase/AMP-PNP
1zxn		Human DNA topoisomerase IIa ATPase/ADP
2akp		Hsp90 Delta24-N210 mutant
2brc		Structure of a Hsp90 Inhibitor bound to the N-terminus of Yeast Hsp90.
2bre		STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90.
2bsm		Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design
2bt0		Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design
2btz		crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2bu2		crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2bu5		crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2bu6		crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2bu7		crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2bu8		crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2byh		3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone
2byi		3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone
2bz5		Structure-based Discovery of a New Class of Hsp90 Inhibitors
2c2a		Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
2ccs		HUMAN HSP90 WITH 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-3-YL)- BENZENE-1,2-DIOL
2cct		HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL- 2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE
2ccu		HUMAN HSP90 WITH 4-CHLORO-6-(4-(4-(4-METHANESULPHONYL-BENZYL)- PIERAZIN-1-YL)-1H-PYRAZOL-3-YL)-BENZENE-1,3-DIOL
2cg9		Crystal structure of an Hsp90-Sba1 closed chaperone complex
2cgf		A RADICICOL ANALOGUE BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
2ch4		Complex between Bacterial Chemotaxis histidine kinase CheA domains P4 and P5 and receptor-adaptor protein CheW
2e0a		Crystal structure of human pyruvate dehydrogenase kinase 4 in complex with AMPPNP
2esa		GRP94 n-terminal domain bound to geldanamycin: effects of mutants 168-169 KS-AA
2exl		GRP94 N-terminal Domain bound to geldanamycin
2fwy		Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H64
2fwz		Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H71
2fxs		Yeast HSP82 in complex with the novel HSP90 Inhibitor Radamide
2fyp		GRP94 in complex with the novel HSP90 Inhibitor Radester amine
2gfd		GRP94 in complex with the novel HSP90 Inhibitor Radamide
2gqp		N-Domain Of Grp94 In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine
2h55		Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-DZ8
2h8m		N-Domain Of Grp94 In Complex With the 2-Iodo-NECA
2hch		N-Domain Of Grp94 In Complex With the Novel Ligand N-(2-amino)ethyl Carboxyamido Adenosine
2hg1		N-Domain Of Grp94 In Complex With the Novel Ligand N-(2-hydroxyl)ethyl Carboxyamido Adenosine
2hkj		Topoisomerase VI-B bound to radicicol
2iop		Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP
2ioq		Crystal Structure of full-length HTPG, the Escherichia coli HSP90
2ior		Crystal Structure of the N-terminal Domain of HtpG, the Escherichia coli Hsp90, Bound to ADP
2iws		Radicicol analogues bound to the ATP site of HSP90
2iwu		Analogues of radicicol bound to the ATP-binding site of Hsp90
2iwx		Analogues of radicicol bound to the ATP-binding site of Hsp90.
2jjc		Hsp90 alpha ATPase domain with bound small molecule fragment
2jki		Complex of Hsp90 N-terminal and Sgt1 CS domain
2k5b		Human CDC37-HSP90 docking model based on NMR
2o1u		Structure of full length GRP94 with AMP-PNP bound
2o1v		Structure of full length GRP94 with ADP bound
2o1w		Structure of N-terminal plus middle domains (N+M) of GRP94
2pnr		Crystal Structure of the asymmetric Pdk3-l2 Complex
2q2e		Crystal structure of the topoisomerase VI holoenzyme from Methanosarcina mazei
2q8f		Structure of pyruvate dehydrogenase kinase isoform 1
2q8g		Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545
2q8h		Structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (DCA)
2q8i		Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol
2qf6		HSP90 complexed with A56322
2qfo		HSP90 complexed with A143571 and A516383
2qg0		HSP90 complexed with A943037
2qg2		HSP90 complexed with A917985
2uwd		Inhibition of the HSP90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole, isoxazole amide analogs
2vci		4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer
2vcj		4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer
2vw5		Structure Of The Hsp90 Inhibitor 7-O-carbamoylpremacbecin Bound To The N- Terminus Of Yeast Hsp90
2vwc		STRUCTURE OF THE HSP90 INHIBITOR MACBECIN BOUND TO THE N-TERMINUS OF YEAST HSP90.
2wep		Yeast Hsp90 N-terminal domain LI-IV mutant with ADP
2weq		Yeast Hsp90 N-terminal domain LI-IV mutant with Geldanamycin
2wer		Yeast Hsp90 N-terminal domain LI-IV mutant with Radicicol
2wi1		Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
2wi2		Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
2wi3		Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
2wi4		Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
2wi5		Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
2wi6		Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
2wi7		Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
2xab		Structure of HSP90 with an inhibitor bound
2xcm		COMPLEX OF HSP90 N-TERMINAL, SGT1 CS AND RAR1 CHORD2 DOMAIN
2xd6		Hsp90 complexed with a resorcylic acid macrolactone.
2xdk		Structure of HSP90 with small molecule inhibitor bound
2xdl		Structure of HSP90 with small molecule inhibitor bound
2xds		Structure of HSP90 with small molecule inhibitor bound
2xdu		Structure of HSP90 with small molecule inhibitor bound
2xdx		Structre of HSP90 with small molecule inhibitor bound
2xhr		Structure of HSP90 with small molecule inhibitor bound
2xht		Structure of HSP90 with small molecule inhibitor bound
2xhx		Structure of HSP90 with small molecule inhibitor bound
2xjg		Structure of HSP90 with small molecule inhibitor bound
2xjj		Structure of HSP90 with small molecule inhibitor bound
2xjx		Structure of HSP90 with small molecule inhibitor bound
2xk2		Structure of HSP90 with small molecule inhibitor bound
2xx2		Macrolactone Inhibitor bound to HSP90 N-term
2xx4		Macrolactone Inhibitor bound to HSP90 N-term
2xx5		Macrolactone Inhibitor bound to HSP90 N-term
2ye2		HSP90 inhibitors and drugs from fragment and virtual screening
2ye3		HSP90 inhibitors and drugs from fragment and virtual screening
2ye4		HSP90 inhibitors and drugs from fragment and virtual screening
2ye5		HSP90 inhibitors and drugs from fragment and virtual screening
2ye6		HSP90 inhibitors and drugs from fragment and virtual screening
2ye7		HSP90 inhibitors and drugs from fragment and virtual screening
2ye8		HSP90 inhibitors and drugs from fragment and virtual screening
2ye9		HSP90 inhibitors and drugs from fragment and virtual screening
2yea		HSP90 inhibitors and drugs from fragment and virtual screening
2yeb		HSP90 inhibitors and drugs from fragment and virtual screening
2yec		HSP90 inhibitors and drugs from fragment and virtual screening
2yed		HSP90 inhibitors and drugs from fragment and virtual screening
2yee		HSP90 inhibitors and drugs from fragment and virtual screening
2yef		HSP90 inhibitors and drugs from fragment and virtual screening
2yeg		HSP90 inhibitors and drugs from fragment and virtual screening
2yeh		HSP90 inhibitors and drugs from fragment and virtual screening
2yei		HSP90 inhibitors and drugs from fragment and virtual screening
2yej		HSP90 inhibitors and drugs from fragment and virtual screening
2yga		E88G-N92L Mutant of N-Term HSP90 complexed with Geldanamycin
2yge		E88G-N92L Mutant of N-Term HSP90 complexed with Geldanamycin
2ygf		L89V, L93I and V136M Mutant of N-Term HSP90 complexed with Geldanamycin
2yi0		Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
2yi5		Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
2yi6		Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
2yi7		Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
2yjw		Tricyclic series of Hsp90 inhibitors
2yjx		Tricyclic series of Hsp90 inhibitors
2yk2		Tricyclic series of Hsp90 inhibitors
2yk9		Tricyclic series of Hsp90 inhibitors
2ykb		Tricyclic series of Hsp90 inhibitors
2ykc		Tricyclic series of Hsp90 inhibitors
2yke		Tricyclic series of Hsp90 inhibitors
2yki		Tricyclic series of Hsp90 inhibitors
2ykj		Tricyclic series of Hsp90 inhibitors
2zbk		Crystal structure of an intact type II DNA topoisomerase: insights into DNA transfer mechanisms
2zdx		Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4
2zdy		Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4
2zkj		Crystal structure of human PDK4-ADP complex
3a0r		Crystal structure of histidine kinase ThkA (TM1359) in complex with response regulator protein TrrA (TM1360)
3a0t		Catalytic domain of histidine kinase ThkA (TM1359) in complex with ADP and Mg ion (trigonal)
3a0w		Catalytic domain of histidine kinase ThkA (TM1359) for MAD phasing (nucleotide free form 2, orthorombic)
3a0x		Catalytic domain of histidine kinase ThkA (TM1359) (nucleotide free form 1: ammomium phosphate, monoclinic)
3a0y		Catalytic domain of histidine kinase ThkA (TM1359) (nucleotide free form 3: 1,2-propanediol, orthorombic)
3a0z		Catalytic domain of histidine kinase ThkA (TM1359) (nucleotide free form 4: isopropanol, orthorombic)
3b24		Hsp90 alpha N-terminal domain in complex with an aminotriazine fragment molecule
3b25		Hsp90 alpha N-terminal domain in complex with an inhibitor CH4675194
3b26		Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850
3b27		Hsp90 alpha N-terminal domain in complex with an inhibitor Ro4919127
3b28		Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765
3bm9		Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90
3bmy		Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90
3c0e		Yeast Hsp82 N-terminal domain: effects of mutants 98-99 KS-AA
3c11		Yeast Hsp82 N-terminal domain-Geldanamycin complex: effects of mutants 98-99 KS-AA
3cgy		Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain in complex with radicicol
3cgz		Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain
3crk		Crystal structure of the PDHK2-L2 complex.
3crl		Crystal structure of the PDHK2-L2 complex.
3d0b		Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90
3d2r		Crystal structure of pyruvate dehydrogenase kinase isoform 4 in complex with ADP
3d36		How to Switch Off a Histidine Kinase: Crystal Structure of Geobacillus stearothermophilus KinB with the Inhibitor Sda
3dge		Structure of a histidine kinase-response regulator complex reveals insights into Two-component signaling and a novel cis-autophosphorylation mechanism
3ehf		Crystal structure of DesKC in complex with AMP-PCP
3ehg		Crystal structure of the ATP-binding domain of DesK in complex with ATP
3ehh		Crystal structure of DesKC-H188V in complex with ADP
3ehj		Crystal structure of DesKC-H188V in complex with AMP-PCP
3eko		Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone
3ekr		Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone
3ft5		Structure of HSP90 bound with a novel fragment
3ft8		Structure of HSP90 bound with a noval fragment.
3fv5		Crystal Structure of E. coli Topoisomerase IV co-complexed with inhibitor
3g75		Crystal structure of Staphylococcus aureus Gyrase B co-complexed with 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE inhibitor
3g7b		Staphylococcus aureus Gyrase B co-complex with METHYL ({5-[4-(4-HYDROXYPIPERIDIN-1-YL)-2-PHENYL-1,3-THIAZOL-5-YL]-1H-PYRAZOL-3-YL}METHYL)CARBAMATE inhibitor
3g7e		Crystal structure of E. coli Gyrase B co-complexed with PROP-2-YN-1-YL {[5-(4-PIPERIDIN-1-YL-2-PYRIDIN-3-YL-1,3-THIAZOL-5-YL)-1H-PYRAZOL-3-YL]METHYL}CARBAMATE inhibitor
3gie		Crystal structure of DesKC_H188E in complex with AMP-PCP
3gif		Crystal structure of DesKC_H188E in complex with ADP
3gig		Crystal structure of phosphorylated DesKC in complex with AMP-PCP
3h4l		Crystal Structure of N terminal domain of a DNA repair protein
3h80		Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LmjF33.0312:M1-K213
3hek		HSP90 N-terminal domain in complex with 1-{4-[(2R)-1-(5-chloro-2,4-dihydroxybenzoyl)pyrrolidin-2-yl]benzyl}-3,3-difluoropyrrolidinium
3hhu		Human heat-shock protein 90 (HSP90) in complex with {4-[3-(2,4-dihydroxy-5-isopropyl-phenyl)-5-thioxo- 1,5-dihydro-[1,2,4]triazol-4-yl]-benzyl}-carbamic acid ethyl ester {ZK 2819}
3hyy		Crystal structure of Hsp90 with fragment 37-D04
3hyz		Crystal structure of Hsp90 with fragment 42-C03
3hz1		Crystal structure of Hsp90 with fragments 37-D04 and 42-C03
3hz5		Crystal structure of Hsp90 with fragment Z064
3ied		Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF14_0417) in complex with AMPPN
3inw		HSP90 N-TERMINAL DOMAIN with pochoxime A
3inx		HSP90 N-TERMINAL DOMAIN with pochoxime B
3ja6		3JA6
3jz3		Structure of the cytoplasmic segment of histidine kinase QseC
3k60		Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF07_0029) bound to ADP
3k97		HSP90 N-terminal domain in complex with 4-chloro-6-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol
3k98		HSP90 N-terminal domain in complex with (1R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide
3k99		HSP90 N-terminal domain in complex with 4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)benzene-1,3-diol
3ke6		The crystal structure of the RsbU and RsbW domains of Rv1364c from Mycobacterium tuberculosis
3lnu		Crystal structure of ParE subunit
3lps		Crystal structure of parE
3mnr		Crystal Structure of Benzamide SNX-1321 bound to Hsp90
3nmq		Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor
3o0i		Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor PU-H54
3o2f		Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54
3o6o		Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of an the inhibitor BIIB021
3omu		Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative
3opd		Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a benzamide derivative
3ow6		Crystal Structure of HSP90 with N-Aryl-benzimidazolone I
3owb		Crystal Structure of HSP90 with VER-49009
3owd		Crystal Structure of HSP90 with N-Aryl-benzimidazolone II
3peh		Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative
3pej		Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of Macbecin
3q5j		Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of 17-DMAP-geldanamycin
3q5k		Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of an inhibitor
3q5l		Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K 213 in the presence of 17-AEP-geldanamycin
3qdd		HSP90A N-terminal domain in complex with BIIB021
3qtf		Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity
3r4m		Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
3r4n		Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
3r4o		Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
3r4p		Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
3r91		Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
3r92		Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.
3rkz		Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor capable of significantly decreasing tumor volume in a mouse xenograft model.
3rlp		Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-6-methylpyrimidin-2-amine
3rlq		Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile
3rlr		Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
3sl2		ATP Forms a Stable Complex with the Essential Histidine Kinase WalK (YycG) Domain
3t0h		Structure insights into mechanisms of ATP hydrolysis and the activation of human Hsp90
3t0z		Hsp90 N-terminal domain bound to ATP
3t10		HSP90 N-terminal domain bound to ACP
3t1k		HSP90 N-terminal domain bound to ANP
3t2s		HSP90 N-terminal domain bound to AGS
3ttz		Crystal structure of a topoisomerase ATPase inhibitor
3tuh		Crystal Structure of the N-terminal domain of an HSP90 in the presence of an the inhibitor ganetespib
3tz0		Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex
3tz2		Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/phenylbutyrate complex
3tz4		Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex with ADP
3tz5		Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/phenylbutyrate complex with ADP
3u2d		S. aureus GyrB ATPase domain in complex with small molecule inhibitor
3u2k		S. aureus GyrB ATPase domain in complex with a small molecule inhibitor
3u67		Crystal structure of the N-terminal domain of Hsp90 from Leishmania major(LmjF33.0312)in complex with ADP
3ur1		The structure of a ternary complex between CheA domains P4 and P5 with CheW and with a truncated fragment of TM14, a chemoreceptor analog from Thermotoga maritima.
3vad		Crystal structure of I170F mutant branched-chain alpha-ketoacid dehydrogenase kinase in complex with 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid
3vha		Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor
3vhc		Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor
3vhd		Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor, CH5164840
3wha		Hsp90 alpha N-terminal domain in complex with a tricyclic inhibitor
3wq9		3WQ9
3zkb		CRYSTAL STRUCTURE OF THE ATPASE REGION OF Mycobacterium tuberculosis GyrB WITH AMPPNP
3zkd		CRYSTAL STRUCTURE OF THE ATPASE REGION OF Mycobacterium tuberculosis GyrB WITH AMPPNP
3zm7		CRYSTAL STRUCTURE OF THE ATPASE REGION OF Mycobacterium tuberculosis GyrB WITH AMPPCP
3zxo		CRYSTAL STRUCTURE OF THE MUTANT ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOSS
3zxq		CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST
4as9		The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90
4asa		The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90
4asb		The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90
4asf		The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90
4asg		The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90
4awo		Complex of HSP90 ATPase domain with tropane derived inhibitors
4awp		Complex of HSP90 ATPase domain with tropane derived inhibitors
4awq		Complex of HSP90 ATPase domain with tropane derived inhibitors
4b6c		Structure of the M. smegmatis GyrB ATPase domain in complex with an aminopyrazinamide
4b7p		Structure of HSP90 with NMS-E973 inhibitor bound
4bae		Optimisation of pyrroleamides as mycobacterial GyrB ATPase inhibitors: Structure Activity Relationship and in vivo efficacy in the mouse model of tuberculosis
4biu		Crystal structure of CpxAHDC (orthorhombic form 1)
4biv		Crystal structure of CpxAHDC (trigonal form)
4biw		Crystal structure of CpxAHDC (hexagonal form)
4bix		Crystal structure of CpxAHDC (monoclinic form 1)
4biy		Crystal structure of CpxAHDC (monoclinic form 2)
4biz		Crystal structure of CpxAHDC (orthorhombic form 2)
4bqg		structure of HSP90 with an inhibitor bound
4bqj		structure of HSP90 with an inhibitor bound
4bxi		4BXI
4cb0		Crystal structure of CpxAHDC in complex with ATP (hexagonal form)
4ce1		Hsp90 N-terminal domain bound to macrolactam analogues of radicicol.
4ce2		Hsp90 N-terminal domain bound to macrolactam analogues of radicicol.
4ce3		Hsp90 N-terminal domain bound to macrolactam analogues of radicicol.
4cti		Escherichia coli EnvZ histidine kinase catalytic part fused to Archaeoglobus fulgidus Af1503 HAMP domain
4cwf		4CWF
4cwn		4CWN
4cwo		4CWO
4cwp		4CWP
4cwq		4CWQ
4cwr		4CWR
4cws		4CWS
4cwt		4CWT
4duh		Crystal structure of 24 kDa domain of E. coli DNA gyrase B in complex with small molecule inhibitor
4dzy		Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(S)-2-chloro-3-phenylpropanoic acid complex with ADP
4e00		Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with ADP
4e01		Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with AMPPNP
4e02		Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(S)-2-chloro-3-phenylpropanoic acid complex with AMPPNP
4eeh		Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-(4-Hydroxy-phenyl)-1H-indazol-6-ol
4eft		Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-Cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)-propionitrile
4efu		Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid benzyl-methyl-amide
4egh		Hsp90-alpha ATPase domain in complex with (4-Hydroxyphenyl)morpholin-4-yl methanone
4egi		Hsp90-alpha ATPase domain in complex with 2-Amino-4-ethylthio-6-methyl-1,3,5-triazine
4egk		Human Hsp90-alpha ATPase domain bound to Radicicol
4em7		Crystal structure of a topoisomerase ATP inhibitor
4emv		Crystal structure of a topoisomerase ATP inhibitor
4fcp		Targetting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo [2,3-d] pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization
4fcq		Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization
4fcr		Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization
4gcz		Structure of a blue-light photoreceptor
4gee		Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
4gfh		Topoisomerase II-DNA-AMPPNP complex
4gfn		Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic
4ggl		Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity
4gqt		N-terminal domain of C. elegans Hsp90
4gt8		Crystal Structure of the Catalytic and ATP-binding Domain from VraS in Complex with ADP
4h7q		Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and ADP
4h81		Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(R)-2-chloro-3-phenylpropanoic acid complex with ADP
4h85		Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(R)-alpha-chloroisocaproate complex with ADP
4hxw		Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
4hxz		Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
4hy1		Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
4hy6		Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1
4hym		Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
4hyp		Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
4hz0		Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
4hz5		Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity
4i3h		A three-gate structure of topoisomerase IV from Streptococcus pneumoniae
4i5s		Structure and function of sensor histidine kinase
4ipe		Crystal structure of mitochondrial Hsp90 (TRAP1) with AMPPNP
4ivg		Crystal structure of mitochondrial Hsp90 (TRAP1) NTD-Middle domain dimer with AMPPNP
4iyn		Structure of mitochondrial Hsp90 (TRAP1) with ADP-ALF4-
4j0b		Structure of mitochondrial Hsp90 (TRAP1) with ADP-BeF3
4jas		Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E and RR468mutant V13P, L14I, I17M and N21V)
4jau		Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E)
4jav		Structural basis of a rationally rewired protein-protein interface (HK853wt and RR468mutant V13P, L14I, I17M and N21V)
4jpb		The structure of a ternary complex between CheA domains P4 and P5 with CheW and with an unzipped fragment of TM14, a chemoreceptor analog from Thermotoga maritima.
4jql		Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid
4juo		A low-resolution three-gate structure of topoisomerase IV from Streptococcus pneumoniae in space group H32
4k4o		The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor
4kfg		The DNA Gyrase B ATP binding domain of Escherichia coli in complex with a small molecule inhibitor.
4kp4		Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.
4kqv		Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor
4ksg		Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (4-[(1S,5R,6R)-6-AMINO-1-METHYL-3-AZABICYCLO[3.2.0]HEPT-3-YL]-6-FLUORO-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE)
4ksh		Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)
4ktn		Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor ((3S)-1-[2-(PYRIDO[2,3-B]PYRAZIN-7-YLSULFANYL)-9H-PYRIMIDO[4,5-B]INDOL-4-YL]PYRROLIDIN-3-AMINE)
4l8z		4L8Z
4l90		4L90
4l91		4L91
4l93		4L93
4l94		4L94
4lp0		Crystal structure of a topoisomerase ATP inhibitor
4lpb		Crystal structure of a topoisomerase ATPase inhibitor
4lwe		4LWE
4lwf		4LWF
4lwg		4LWG
4lwh		4LWH
4lwi		4LWI
4mb9		Structure of Streptococcus pneumonia ParE in complex with AZ13102335
4mbc		Structure of Streptococcus pneumonia ParE in complex with AZ13053807
4mot		Structure of Streptococcus pneumonia pare in complex with AZ13072886
4mp2		Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PA1
4mp7		Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PA7
4mpc		Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS2
4mpe		Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS8
4mpn		Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS10
4nh7		Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
4nh8		Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
4nh9		Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
4o04		4O04
4o05		Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease
4o07		Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease
4o09		Identification of novel HSP90 / isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington s disease
4o0b		Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease
4p7a		Crystal Structure of human MLH1
4p8o		4P8O
4pl9		4PL9
4prv		4PRV
4prx		4PRX
4pu9		4PU9
4q20		Crystal structure of a C-terminal part of tyrosine kinase (DivL) from Caulobacter crescentus CB15 at 2.50 A resolution (PSI Community Target, Shapiro)
4r1f		4R1F
4r39		4R39
4r3a		4R3A
4r3m		4R3M
4u7n		4U7N
4u7o		4U7O
4u93		4U93
4url		4URL
4urm		4URM
4urn		4URN
4uro		4URO
4v25		4V25
4v26		4V26
4w7t		4W7T
4wub		4WUB
4wuc		4WUC
4wud		4WUD
4x9l		4X9L
4xc0		4XC0
4xcj		4XCJ
4xcl		4XCL
4xd8		4XD8
4xdm		4XDM
4xe2		4XE2
4xip		4XIP
4xiq		4XIQ
4xir		4XIR
4xit		4XIT
4xiv		4XIV
4xka		4XKA
4xkk		4XKK
4xko		4XKO
4xtj		4XTJ
4ykq		4YKQ
4ykr		4YKR
4ykt		4YKT
4yku		4YKU
4ykw		4YKW
4ykx		4YKX
4yky		4YKY
4ykz		4YKZ
4z1f		4Z1F
4z1g		4Z1G
4z1h		4Z1H
4z1i		4Z1I
4zki		4ZKI
4zvi		4ZVI
5akb		5AKB
5akc		5AKC
5akd		5AKD
5boc		5BOC
5bod		5BOD
5c93		5C93
5cf0		5CF0
5cph		5CPH
5ctu		5CTU
5ctw		5CTW
5ctx		5CTX
5cty		5CTY
5d6p		5D6P
5d6q		5D6Q
5d7c		5D7C
5d7d		5D7D
5d7r		5D7R
5f3k		5F3K
5f5r		5F5R
5fnc		5FNC
5fnd		5FND
5fnf		5FNF
5fwk		5FWK
5fwl		5FWL
5fwm		5FWM
5fwp		5FWP
5hph		5HPH
5idj		5IDJ
5idm		5IDM
5in9		5IN9
5l3j		5L3J

Links (links to other resources describing this domain)
INTERPRO IPR003594

HATPase_c

Taxonomic distribution of proteins containing HATPase_c domain.

3D Structures of HATPase_c domains in PDB