HRDCHelicase and RNase D C-terminal
|SMART accession number:||SM00341
||Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.|
|Interpro abstract (IPR002121):
||The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain associated with the human BLM gene result in Bloom Syndrome (BS), an autosomal recessive disorder characterised by proportionate pre- and postnatal growth deficiency; sun-sensitive, telangiectatic, hypo- and hyperpigmented skin; predisposition to malignancy; and chromosomal instability [(PUBMED:9397680)].
|GO component:||intracellular (GO:0005622)|
|GO function:||nucleic acid binding (GO:0003676)|
There are 1443
HRDC domains in 1360 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
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