Letunic et al. (2014) Nucleic Acids Res doi: 10.1093/nar/gku949
Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922

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LON Found in ATP-dependent protease La (LON)

SMART accession number:	SM00464
Description:	N-terminal domain of the ATP-dependent protease La (LON), present also in other bacterial ORFs.
Interpro abstract (IPR003111):	This signature defines the N-terminal substrate-binding domain of the archael, bacterial and eukaryotic lon proteases, which are ATP-dependent serine peptidases belonging to the MEROPS peptidase family S16 (lon protease family, clan SF). In the eukaryotes the majority of the proteins are located in the mitochondrial matrix [(PUBMED:8248235), (PUBMED:9620272)]. In yeast, Pim1, is located in the mitochondrial matrix, is required for mitochondrial function, is constitutively expressed but is increased after thermal stress, suggesting that Pim1 may play a role in the heat shock response [(PUBMED:8276800)]. This structure of this domain has been determined [(PUBMED:16199667), (PUBMED:19191354), (PUBMED:20834233)]. This domain also occurs in proteins which lack the peptidase domain, such as the SPBC14F5.10c gene product from Schizosaccharomyces pombe; these proteins are uncharacterized.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 17617 LON domains in 17613 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing LON domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with LON domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing LON domain in the selected taxonomic class.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 50.00 map00240 Pyrimidine metabolism 50.00 map00230 Purine metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with LON domain which could be assigned to a KEGG orthologous group, and not all proteins containing LON domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of LON domains in PDB

  PDB code	Main view	Title
  1zbo		X-Ray Crystal Structure of Protein BPP1347 from Bordetella parapertussis. Northeast Structural Genomics Consortium Target BoR27.
  2ane		Crystal structure of N-terminal domain of E.Coli Lon Protease
  3ljc		Crystal structure of Lon N-terminal domain.
  3m65		Crystal structure of Bacillus subtilis Lon N-terminal domain
  4ci1		4CI1
  4ci2		4CI2
  4ci3		4CI3
  4tz4		4TZ4
  5fqd		5FQD
  5hxb		5HXB

• Links (links to other resources describing this domain)

• INTERPRO	IPR003111
  PROSITE	LON_SER

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