RICTOR_V

Rapamycin-insensitive companion of mTOR, domain 5
RICTOR_V
SMART accession number:SM01310
Description: Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.
Interpro abstract (IPR029452):

The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 [ (PUBMED:15268862) ]. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling [ (PUBMED:19995915) ]. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [ (PUBMED:18089801) ].

This entry represent the conserved domain 5 of the Rictor (Rapamycin-insensitive companion of mTOR) protein.

Family alignment:
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There are 1479 RICTOR_V domains in 1476 proteins in SMART's nrdb database.

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