DEPDomain found in Dishevelled, Egl-10, and Pleckstrin |
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| SMART accession number: | SM00049 |
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| Description: | Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118). |
| Interpro abstract (IPR000591): | This is a domain of unknown function present in signaling proteins including dishevelled, Egl-10, and pleckstrin proteins. Segment polarity dishevelled protein is required to establish coherent arrays of polarized cells and segments in embryos, and plays a role in wingless signaling. Egl-10 regulates G-protein signaling in the central nervous system. Mammalian regulators of G-protein signaling also contain these domains, and regulate signal transduction by increasing the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form. |
| GO process: | intracellular signaling cascade (GO:0007242) |
| Family alignment: |
There are 896 DEP domains in 785 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
- Cellular role (predicted cellular role)
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- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
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