FN3Fibronectin type 3 domain |
 |
|---|
| SMART accession number: | SM00060 |
|---|---|
| Description: | One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins. |
| Interpro abstract (IPR003961): | Fibronectins are multi-domain glycoproteins found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes [(PUBMED:3780752)]. They contain multiple copies of 3 repeat regions (types I, II and III), which bind to a variety of substances including heparin, collagen, DNA, actin, fibrin and fibronectin receptors on cell surfaces. The wide variety of these substances means that fibronectins are involved in a number of important functions: e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis [(PUBMED:3031656)]. The role of fibronectin in cell differentiation is demonstrated by the marked reduction in the expression of its gene when neoplastic transformation occurs. Cell attachment has been found to be mediated by the binding of the tetrapeptide RGDS to integrins on the cell surface [(PUBMED:2466295)], although related sequences can also display cell adhesion activity. Plasma fibronectin occurs as a dimer of 2 different subunits, linked together by 2 disulphide bonds near the C terminus. The difference in the 2 chains occurs in the type III repeat region and is caused by alternative splicing of the mRNA from one gene [(PUBMED:3780752)]. The observation that, in a given protein, an individual repeat of one of the 3 types (e.g., the first FnIII repeat) shows much less similarity to its subsequent tandem repeats within that protein than to its equivalent repeat between fibronectins from other species, has suggested that the repeating structure of fibronectin arose at an early stage of evolution. It also seems to suggest that the structure is subject to high selective pressure [(PUBMED:6317187)]. The fibronectin type III repeat region is an approximately 100 amino acid domain, different tandem repeats of which contain binding sites for DNA, heparin and the cell surface [(PUBMED:3780752)]. The superfamily of sequences believed to contain FnIII repeats represents 45 different families, the majority of which are involved in cell surface binding in some manner, or are receptor protein tyrosine kinases, or cytokine receptors. |
| GO function: | protein binding (GO:0005515) |
| Family alignment: |
There are 44533 FN3 domains in 13692 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
-
Click on
to expand nodes. To display all proteins with a FN3 domain in a specific node, click on it.This tree shows only several representative species. The complete taxonomic breakdown of all proteins with FN3 domain is also avaliable.
Useful shortcuts: Expand all nodes or Collapse tree
Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes - Literature (relevant references for this domain)
-
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Leahy DJ, Aukhil I, Erickson HP
- 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.
- Cell. 1996; 84: 155-64
- Display abstract
We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.
- Huber AH, Wang YM, Bieber AJ, Bjorkman PJ
- Crystal structure of tandem type III fibronectin domains from Drosophila neuroglian at 2.0 A.
- Neuron. 1994; 12: 717-31
- Display abstract
We report the crystal structure of two adjacent fibronectin type III repeats from the Drosophila neural cell adhesion molecule neuroglian. Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. beta bulges and left-handed polyproline II helices disrupt the regular beta sheet structure of both neuroglian domains. The hydrophobic interdomain interface includes a metal-binding site, presumably involved in stabilizing the relative orientation between domains and predicted by sequence comparision to be present in the vertebrate homolog molecule L1. The neuroglian domains are related by a near perfect 2-fold screw axis along the longest molecular dimension. Using this relationship, a model for arrays of tandem fibronectin type III repeats in neuroglian and other molecules is proposed.
- Potts JR, Campbell ID
- Fibronectin structure and assembly.
- Curr Opin Cell Biol. 1994; 6: 648-55
- Display abstract
Significant progress has been made recently in the determination of the structure and assembly of the important matrix protein fibronectin, a molecule mainly constructed from three modular units denoted Fn1, Fn2 and Fn3. Atomic resolution structures are now available for all three single modules, for Fn1 and Fn3 module pairs, and for the disulphide-linked join between fibronectin monomers. Combined with results from new binding and mutation studies, the new structural information is leading to a clearer view of structure/function relationships in intact fibronectin.
- Skorstengaard K, Holtet TL, Etzerodt M, Thogersen HC
- Collagen-binding recombinant fibronectin fragments containing type II domains.
- FEBS Lett. 1994; 343: 47-50
- Display abstract
Each of the two type II domains and four larger fragments, containing one or two type II domains of fibronectin, have been expressed in Escherichia coli. A special vector, containing a fragment encoding the cleavage site for Factor Xa, Ile-Glu-Gly-Arg, inserted immediately before the protein fragment of interest, was used. After treatment of the purified fusion proteins with reduced/oxidized glutathione, the correctly folded fibronectin fragments were released by proteolytic digestion with Factor Xa. The largest fragment, consisting of two type II and two type I domains, was the only fragment able to bind to immobilized gelatin.
- Leahy DJ, Hendrickson WA, Aukhil I, Erickson HP
- Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.
- Science. 1992; 258: 987-91
- Display abstract
Fibronectin type III domains are found in many different proteins including cell surface receptors and cell adhesion molecules. The crystal structure of one such domain from the extracellular matrix protein tenascin was determined. The structure was solved by multiwavelength anomalous diffraction (MAD) phasing of the selenomethionyl protein and has been refined to 1.8 angstrom resolution. The folding topology of this domain is identical to that of the extracellular domains of the human growth hormone receptor, the second domain of CD4, and PapD. Although distinct, this topology is similar to that of immunoglobulin constant domains. An Arg-Gly-Asp (RGD) sequence that can function for cell adhesion is found in a tight turn on an exposed loop.
- Main AL, Harvey TS, Baron M, Boyd J, Campbell ID
- The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions.
- Cell. 1992; 71: 671-8
- Display abstract
The solution structure of the tenth type III module of fibronectin has been determined using nuclear magnetic resonance techniques. The molecule has a fold similar to that of immunoglobulin domains, with seven beta strands forming two antiparallel beta sheets, which pack against each other. Both beta sheets contribute conserved hydrophobic residues to a compact core. The topology is more similar to that of domain 2 of CD4, PapD, and the extracellular domain of the human growth hormone receptor than to that of immunoglobulin C domains. The module contains an Arg-Gly-Asp sequence known to be involved in cell adhesion. This tripeptide is solvent exposed and lies on a conformationally mobile loop between strands F and G, consistent with its cell adhesion function.
- Petersen TE et al.
- Partial primary structure of bovine plasma fibronectin: three types of internal homology.
- Proc Natl Acad Sci U S A. 1983; 80: 137-41
- Balian G, Click EM, Bornstein P
- Location of a collagen-binding domain in fibronectin.
- J Biol Chem. 1980; 255: 3234-6
- Display abstract
Preferential labeling of COOH-terminal sequences in newly synthesized fibronectin was achieved by short term incorporation of radiolabeled amino acids in the presence of pactamycin, an inhibitor of polypeptide chain initiation. The labeled fibronectin was then cleaved with cathepsin D under conditions that yield a large (137,000-dalton) fragment that lacks collagen-binding properties, and a smaller (72,000-dalton) fragment that retains the ability of fibronectin to bind to collagen. Determination of the relative specific radioactivities of the two fragments leads us to conclude that the collagen-binding domain in fibronectin is located in the NH2-terminal third of the polypeptide chain and not in a COOH-terminal region as previously indicated by other structural studies.
- Disease (disease genes where sequence variants are found in this domain)
-
SwissProt sequences and OMIM curated human diseases associated with missense mutations within the FN3 domain.
Protein Disease Anosmin-1 (P23352) (SMART) OMIM:308700: Kallmann syndrome Leptin receptor (P48357) (SMART) OMIM:601007: LEPTIN RECEPTOR; LEPR Collagen alpha-1(VII) chain (Q02388) (SMART) OMIM:120120: Epidermolysis bullosa dystrophica, dominant
OMIM:131750: Epidermolysis bullosa dystrophica, recessive
OMIM:226600: Epidermolysis bullosa, pretibial, dominant and recessive
OMIM:131850:Cytokine receptor common subunit gamma (P31785) (SMART) OMIM:308380: Severe combined immunodeficiency, X-linked
OMIM:300400: Combined immunodeficiency, X-linked, moderate
OMIM:312863:Neural cell adhesion molecule L1 (P32004) (SMART) OMIM:308840: Hydrocephalus due to aqueductal stenosis
OMIM:307000: MASA syndrome
OMIM:303350: Spastic paraplegia
OMIM:312900:Insulin receptor subunit beta (P06213) (SMART) OMIM:147670: Leprechaunism
OMIM:246200: Rabson-Mendenhall syndrome
OMIM:262190: Diabetes mellitus, insulin-resistant, with acanthosis nigricansIntegrin beta-4 (P16144) (SMART) OMIM:147557: Epidermolysis bullosa, junctional, with pyloric atresia
OMIM:226730: Epidermolysis bullosa, generalized atrophic benign
OMIM:226650: - Metabolism (metabolic pathways involving proteins which contain this domain)
-
Click the image to view the interactive version of the map in iPath% proteins involved KEGG pathway ID Description 21.19 map04060 Cytokine-cytokine receptor interaction 13.17 map04360 Axon guidance 8.71 map04514 Cell adhesion molecules (CAMs) 7.56 map04510 Focal adhesion 5.15 map04512 ECM-receptor interaction 5.15 map04640 Hematopoietic cell lineage 4.81 map04520 Adherens junction 3.21 map04810 Regulation of actin cytoskeleton 2.75 
map00530Aminosugars metabolism 2.63 map04080 Neuroactive ligand-receptor interaction 1.72 map05210 Colorectal cancer 1.72 map04650 Natural killer cell mediated cytotoxicity 1.60 map04910 Insulin signaling pathway 1.60 map05215 Prostate cancer 1.15 map05214 Glioma 1.15 map04620 Toll-like receptor signaling pathway 1.15 map04730 Long-term depression 1.15 map05218 Melanoma 1.15 map04914 Progesterone-mediated oocyte maturation 1.03 map04920 Adipocytokine signaling pathway 1.03 map04020 Calcium signaling pathway 0.92 map05222 Small cell lung cancer 0.92 map05120 Epithelial cell signaling in Helicobacter pylori infection 0.92 map05050 Dentatorubropallidoluysian atrophy (DRPLA) 0.92 map04210 Apoptosis 0.92 map04930 Type II diabetes mellitus 0.80 map04120 Ubiquitin mediated proteolysis 0.80 map04660 T cell receptor signaling pathway 0.57 map00500Starch and sucrose metabolism 0.46 map00361gamma-Hexachlorocyclohexane degradation 0.34 map04740 Olfactory transduction 0.34 map00790Folate biosynthesis 0.34 map02020 Two-component system - General 0.34 map00511 N-Glycan degradation 0.34 map01032 Glycan structures - degradation 0.23 map00531Glycosaminoglycan degradation 0.23 map04010 MAPK signaling pathway 0.23 map04940 Type I diabetes mellitus 0.23 map00604Glycosphingolipid biosynthesis - ganglioseries 0.23 map00600Sphingolipid metabolism 0.11 map00603Glycosphingolipid biosynthesis - globoseries 0.11 map00780Biotin metabolism 0.11 map00740Riboflavin metabolism 0.11 map00300Lysine biosynthesis 0.11 map00310Lysine degradation 0.11 map00561Glycerolipid metabolism 0.11 map00052Galactose metabolism 0.11 map02010 ABC transporters - General 0.11 map00520Nucleotide sugars metabolism 0.11 map00550Peptidoglycan biosynthesis This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with FN3 domain which could be assigned to a KEGG orthologous group, and not all proteins containing FN3 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of FN3 domains in PDB
PDB code Main view Title 1a22 
Human growth hormone bound to single receptor 1axi 
Structural plasticity at the hgh:hghbp interface 1bj8 
Third n-terminal domain of gp130, nmr, minimized average structure 1bp3 
The xray structure of a growth hormone-prolactin receptor complex 1bpv 
Titin module a71 from human cardiac muscle, nmr, 50 structures 1bqu 
Cytokyne-binding region of gp130 1c8p 
Nmr structure of the ligand binding domain of the common beta-chain in the gm-csf, il-3 and il-5 receptors 1cfb 
Crystal structure of tandem type iii fibronectin domains from drosophila neuroglian at 2.0 angstroms 1cn4 
Erythropoietin complexed with extracellular domains of erythropoietin receptor 1eba 
Complex between the extracellular domain of erythropoietin (epo) receptor [ebp] and an inactive peptide [emp33] contains 3,5-dibromotyrosine in position 4 (denoted dby) 1ebp 
Complex between the extracellular domain of erythropoietin (epo) receptor [ebp] and an agonist peptide [emp1] 1eer 
Crystal structure of human erythropoietin complexed to its receptor at 1.9 angstroms 1egj 
Domain 4 of the beta common chain in complex with an antibody 1ern 
Native structure of the extracellular domain of erythropoietin (epo) receptor [ebp] 1f6f 
Crystal structure of the ternary complex between ovine placental lactogen and the extracellular domain of the rat prolactin receptor 1fna 
Crystal structure of the tenth type iii cell adhesion module of human fibronectin 1fnf 
Fragment of human fibronectin encompassing type-iii repeats through 10 1fnh 
Crystal structure of heparin and integrin binding segment of human fibronectin 1gh7 
Crystal structure of the complete extracellular domain of the beta-common receptor of il-3, il-5, and gm-csf 1hwg 
1:2 complex of human growth hormone with its soluble binding protein 1hwh 
1:1 complex of human growth hormone mutant g120r with its soluble binding protein 1i1r 
Crystal structure of a cytokine/receptor complex 1iar 
Interleukin-4 / receptor alpha chain complex 1j8k 
Nmr structure of the fibronectin eda domain, nmr, 20 structures 1k85 
Solution structure of the fibronectin type iii domain from bacillus circulans wl-12 chitinase a1. 1kf9 
Phage display derived variant of human growth hormone complexed with two copies of the extracellular domain of its receptor 1lwr 
Solution structure of the ncam fibronectin type iii module 2 1mfn 
Solution nmr structure of linked cell attachment modules of mouse fibronectin containing the rgd and synergy regions, structures 1n26 
Crystal structure of the extra-cellular domains of human interleukin-6 receptor alpha chain 1oww 
Solution structure of the first type iii module of human fibronectin determined by 1h, 15n nmr spectroscopy 1p9m 
Crystal structure of the hexameric human il-6/il-6 alpha receptor/gp130 complex 1pvh 
Crystal structure of leukemia inhibitory factor in complex with gp130 1qg3 
Crystal structure of a tandem pair of fibronectin type iii domains from the cytoplasmic tail of integrin alpha6 beta4 1qr4 
Two fibronectin type-iii domain segment from chicken tenascin 1tdq 
Structural basis for the interactions between tenascins and the c-type lectin domains from lecticans: evidence for a cross-linking role for tenascins 1ten 
Structure of a fibronectin type iii domain from tenascin phased by mad analysis of the selenomethionyl protein 1ttf 
The three-dimensional structure of the tenth type iii module of fibronectin: an insight into rgd-mediated interactions 1ttg 
The three-dimensional structure of the tenth type iii module of fibronectin: an insight into rgd-mediated interactions 1uc6 
Solution structure of the carboxyl terminal domain of the ciliary neurotrophic factor receptor 1uem 
Solution structure of the first fibronectin type iii domain of human kiaa1568 protein 1uen 
Solution structure of the third fibronectin iii domain of human kiaa0343 protein 1uey 
Solution structure of the first fibronectin type iii domain of human kiaa0343 protein 1ujt 
Solution structure of the second fibronectin type iii domain of human kiaa1568 protein 1v5j 
Solution structure of rsgi ruh-008, fn3 domain in human cdna 1va9 
Solution structure of the second fniii domain of dscaml1 protein 1wf5 
Solution structure of the first fn3 domain of sidekick-2 protein 1wfn 
The fourth fn3 domain of human sidekick-2 1wfo 
The eighth fn3 domain of human sidekick-2 1wft 
Solution structure of c-terminal fibronectin type iii domain of mouse 1700129l13rik protein 1wfu 
Solution structure of fibronectin type iii domain of mouse hypothetical protein 1wis 
Solution structure of the fifth fniii domain from human kiaa1514 protein 1wj3 
Solution structure of the fourth fn3 domain of kiaa1496 protein 1wk0 
Solution structure of fibronectin type iii domain derived from human kiaa0970 protein 1x3d 
Solution structure of the fibronectin type-iii domain of human fibronectin type-iii domain containing protein 3a 1x4x 
Solution structure of the 6th fibronectin type iii domain from human fibronectin type iii domain containing protein 3 1x4y 
Solution structure of the 3rd fibronectin type iii domain from mouse biregional cell adhesion molecule-related/down- regulated oncogenes (cdon) binding protein 1x4z 
Solution structure of the 2nd fibronectin type iii domain from mouse biregional cell adhesion molecule-related/down- regulated oncogenes (cdon) binding protein 1x5a 
The solution structure of the second fibronectin type iii domain of mouse ephrin type-a receptor 1 1x5f 
The solution structure of the first fibronectin type iii domain of human neogenin 1x5g 
The solution structure of the second fibronectin type iii domain of human neogenin 1x5h 
The solution structure of the third fibronectin type iii domain of human neogenin 1x5i 
The solution structure of the fourth fibronectin type iii domain of human neogenin 1x5j 
The solution structure of the fifth fibronectin type iii domain of human neogenin 1x5k 
The solution structure of the sixth fibronectin type iii domain of human neogenin 1x5l 
Solution structure of the second fn3 domain of eph receptor a8 protein 1x5x 
Solution structure of the fibronectin type-iii domain of human fibronectin type iii domain containing protein 3 1x5y 
Solution structure of the fibronectin type-iii domain of mouse myosin-binding protein c, fast-type homolog 1x5z 
Solution structure of the fibronectin type-iii domain of human protein tyrosine phosphatase, receptor type, d isoform 4 variant 1zlg 
Solution structure of the extracellular matrix protein anosmin-1 2aew 
A model for growth hormone receptor activation based on subunit rotation within a receptor dimer 2arw 
The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor 2b5i 
Cytokine receptor complex 2ck2 
Structure of core-swapped mutant of fibronectin 2crm 
Solution structure of the forth fniii domain of human 2crz 
Solution structure of the fifth fniii domain of human fibronectin type iii domain containing protein 3a 2csp 
Solution structure of the fniii domain of human rim-binding protein 2 2cuh 
Solution structure of the 31st fibronectin type iii domain of the human tenascin x 2cui 
Solution structure of the 31st fibronectin type iii domain of the human tenascin x 2cum 
The solution structure of the 33rd fibronectin type iii domain of human tenascin-x 2d9q 
Crystal structure of the human gcsf-receptor signaling complex 2db8 
Solution structures of the fn3 domain of human tripartite motif protein 9 2dbj 
Solution structures of the fn3 domain of human proto- oncogene tyrosine-protein kinase mer precursor 2djs 
Solution structures of the fn3 domain of human ephrin type- b receptor 1 2dju 
Solution structures of the fn3 domain of human receptor- type tyrosine-protein phosphatase f 2dkm 
Solution structures of the fn3 domain of human collagen alpha-1(xx) chain 2dle 
Solution structure of the fourth fn3 domain of human receptor-type tyrosine-protein phosphatase eta 2dlh 
Solution structure of the second fn3 domain of human receptor-type tyrosine-protein phosphatase delta 2dm4 
Solution structure of the second fn3 domain of human sorla/lr11 2dmk 
The solution structure of the fn3 domain of human midline 2 protein 2dn7 
Solution structures of the 6th fn3 domain of human receptor- type tyrosine-protein phosphatase f 2doc 
Solution structure of the fibronectin type-iii domain of human neural cell adhesion molecule 2 2dtg 
Insulin receptor (ir) ectodomain in complex with fab's 2e3v 
Crystal structure of the first fibronectin type iii domain of neural cell adhesion molecule splicing isoform from human muscle culture lambda-4.4 2e7h 
Solution structure of the second fn3 domain from human ephrin type-b receptor 4 2ed7 
Solution structure of the first fibronectin type iii domain of human netrin receptor dcc 2ed8 
Solution structure of the second fibronectin type iii domain of human netrin receptor dcc 2ed9 
Solution structure of the third fibronectin type iii domain of human netrin receptor dcc 2edb 
Solution structure of the fourth fibronectin type iii domain of human netrin receptor dcc 2edd 
Solution structure of the fifth fibronectin type iii domain of human netrin receptor dcc 2ede 
Solution structure of the sixth fibronectin type iii domain of human netrin receptor dcc 2edx 
Solution structures of the fn3 domain of human receptor- type tyrosine-protein phosphatase f 2edy 
Solution structures of the fn3 domain of human receptor- type tyrosine-protein phosphatase f 2ee2 
Solution structures of the fn3 domain of human contactin 1 2ee3 
Solution structures of the fn3 domain of human collagen alpha-1(xx) chain 2ekj 
Solution structures of the fn3 domain of human collagen alpha-1(xx) chain 2erj 
Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 2fnb 
Nmr structure of the fibronectin ed-b domain, nmr, 20 structures 2gee 
Crystal structure of human type iii fibronectin extradomain b and domain 8 2gys 
2.7 a structure of the extracellular domains of the human beta common receptor involved in il-3, il-5, and gm-csf signalling 2h41 
Solution structure of the second type iii domain of human fibronectin: minimized average structure 2h45 
Solution structure of the second type iii domain of human fibronectin: ensemble of 25 structures 2ha1 
Complex of the first and second type iii domains of human fibronectin in solution 2haz 
Crystal structure of the first fibronectin domain of human ncam1 2ibb 
Crystal structure of the first and second fniii domains of ihog 2ibg 
Crystal structure of hedgehog bound to the fniii domains of ihog 2ic2 
Crystal structure of the first fniii domain of ihog 2jix 
Crystal structure of abt-007 fab fragment with the soluble domain of epo receptor 2jlk 
Crystal structure of ncam2 igiv-fn3i 2jll 
Crystal structure of ncam2 igiv-fn3ii 2mfn 
Solution nmr structure of linked cell attachment modules of mouse fibronectin containing the rgd and synergy regions, structures 2nzi 
Crystal structure of domains a168-a170 from titin 2obg 
Crystal structure of monobody mbp-74/maltose binding protein fusion complex 2ocf 
Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the e2#23 fn3 monobody 2q7n 
Crystal structure of leukemia inhibitory factor in complex with lif receptor (domains 1-5) 2qbw 
The crystal structure of pdz-fibronectin fusion protein 2rb8 
High resolution design of a protein loop 2rbl 
High resolution design of a protein loop 2uve 
Structure of yersinia enterocolitica family 28 exopolygalacturonase 2uvf 
Structure of yersinia enterocolitica family 28 exopolygalacturonase in complex with digalaturonic acid 2v5y 
Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain 2vkw 
Human ncam, fn3 domains 1 and 2 2vkx 
Human ncam, fn3 domains 1 and 2, m610r mutant 2vtc 
The structure of a glycoside hydrolase family 61 member, cel61b from the hypocrea jecorina. 2w1n 
Cohesin and fibronectin type-iii double module construct from the clostridium perfringens glycoside hydrolase gh84c 2yrz 
Solution structure of the fibronectin type iii domain of human integrin beta-4 2yuw 
Solution structure of 2nd fibronectin domain of slow type myosin-binding protein c 2yux 
Solution structure of 3rd fibronectin type three domain of slow type myosin-binding protein c 3b83 
Tba 3bpl 
Crystal structure of the il4-il4r-common gamma ternary complex 3bpn 
Crystal structure of the il4-il4r-il13ra ternary complex 3bpo 
Crystal structure of the il13-il4r-il13ra ternary complex 3ch8 
The crystal structure of pdz-fibronectin fusion protein 3csb 
Crystal structure of monobody ysx1/maltose binding protein fusion complex 3csg 
Crystal structure of monobody ys1(mbp-74)/maltose binding protein fusion complex 3cxe 
Structure of the gm-csf receptor complex 3d1m 
Crystal structure of sonic hedgehog bound to the third fniii domain of cdo 3d48 
Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor 3e0g 
Structure of the leukemia inhibitory factor receptor (lif- r) domains d1-d5 3ew3 
The 1:2 complex between a nterminal elongated prolactin and the extra cellular domain of the rat prolactin receptor 3f7p 
Crystal structure of a complex between integrin beta4 and plectin 3f7q 
First pair of fibronectin type iii domains and part of the connecting segment of the integrin beta4 3f7r 
First pair of fibronectin type iii domains and part of the connecting segment of the integrin beta4 3fl7 
Crystal structure of the human ephrin a2 ectodomain 3hhr 
Human growth hormone and extracellular domain of its receptor: crystal structure of the complex - Links (links to other resources describing this domain)
-
PFAM fn3 INTERPRO IPR003961 PROSITE FN3_DOMAIN