IL10Interleukin-10 family |
 |
|---|
| SMART accession number: | SM00188 |
|---|---|
| Description: | Interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. |
| Interpro abstract (IPR000098): | Interleukin-10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structurally, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds (PUBMED:8590020). IL-10 is highly similar to the Human herpesvirus 4 (Epstein-Barr virus) BCRF1 protein which inhibits the synthesis of gamma-interferon and to Equid herpesvirus 2 (Equine herpesvirus 2) protein E7. It is also similar, but to a lesser degree, with human protein mda-7 (PUBMED:8545104), a protein which has antiproliferative properties in human melanoma cells. Mda-7 only contains two of the four cysteines of IL-10. |
| GO process: | immune response (GO:0006955) |
| GO component: | extracellular region (GO:0005576) |
| GO function: | cytokine activity (GO:0005125) |
| Family alignment: |
There are 172 IL10 domains in 172 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)
to expand nodes. To display all proteins with a IL10 domain in a specific node, click on it.
