TNFRTumor necrosis factor receptor / nerve growth factor receptor repeats.
|SMART accession number:||SM00208|
|Description:||Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR|
|Interpro abstract (IPR001368):|
A number of proteins, some of which are known to be receptors for growth factors, have been found to contain a cysteine-rich domain of about 110 to 160 amino acids in their N-terminal part, that can be subdivided into four (or in some cases, three) modules of about 40 residues containing 6 conserved cysteines. Some of the proteins containing this domain are listed below [(PUBMED:2174582), (PUBMED:15335933), (PUBMED:15335677)]:
It has been shown [(PUBMED:8387891)] that the six cysteines all involved in intrachain disulphide bonds. A schematic representation of the structure of the 40 residue module of these receptors is shown below:
'C': conserved cysteine involved in a disulphide bond.
|GO function:||protein binding (GO:0005515)|
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- Evolution (species in which this domain is found)
- Literature (relevant references for this domain)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)