SMART: G_alpha domain annotation

G_alpha G protein alpha subunit

SMART accession number:	SM00275
Description:	Subunit of G proteins that contains the guanine nucleotide binding site
Family alignment:	View or

There are 1055 G_alpha domains in 1055 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with G_alpha domain is also avaliable.

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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
Disease (disease genes where sequence variants are found in this domain)

Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

Protein	Disease
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (SRS)(SMART)	OMIM:139320: Pseudohypoparathyroidism, type Ia OMIM:103580: McCune-Albright polyostotic fibrous dysplasia OMIM:174800: Somatotrophinoma ; Pituitary ACTH secreting adenoma
Guanine nucleotide-binding protein G(t), alpha-1 subunit (SRS)(SMART)	OMIM:139330: Night blindness, congenital stationary

3D Structures of G_alpha domains in PDB

PDB code	Main view	Title
1agr		Complex of alf4-activated gi-alpha-1 with rgs4
1as0		Gtp-gamma-s bound g42v gia1
1as2		Gdp+pi bound g42v gia1
1as3		Gdp bound g42v gia1
1azs		Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase
1azt		Gs-alpha complexed with gtp-gamma-s
1bh2		A326s mutant of an inhibitory alpha subunit
1bof		Gi-alpha-1 bound to gdp and magnesium
1cip		Gi-alpha-1 subunit of guanine nucleotide-binding protein complexed with a gtp analogue
1cjk		Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with adenosine 5'-(alpha thio)- triphosphate (rp), mg, and mn
1cjt		Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with beta-l-2',3'-dideoxyatp, mn, and mg
1cju		Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with beta-l-2',3'-dideoxyatp and mg
1cjv		Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with beta-l-2',3'-dideoxyatp, mg, and zn
1cs4		Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with 2'-deoxy-adenosine 3'- monophosphate, pyrophosphate and mg
1cul		Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with 2',5'-dideoxy-adenosine 3'- triphosphate and mg
1fqj		Crystal structure of the heterotrimeric complex of the rgs domain of rgs9, the gamma subunit of phosphodiesterase and the gt/i1 chimera alpha subunit [(rgs9)-(pdegamma)- (gt/i1alpha)-(gdp)-(alf4-)-(mg2+)]
1fqk		Crystal structure of the heterodimeric complex of the rgs domain of rgs9, and the gt/i1 chimera alpha subunit [(rgs9)-(gt/i1alpha)-(gdp)-(alf4-)-(mg2+)]
1gdd		Tertiary and quaternary structural changes in gia1 induced by gtp hydrolysis
1gfi		Structures of active conformations of gi alpha 1 and the mechanism of gtp hydrolysis
1gg2		G protein heterotrimer mutant gi_alpha_1(g203a) beta_1 gamma_2 with gdp bound
1gia		Structure of active conformations of gia1 and the mechanism of gtp hydrolysis
1gil		Structure of active conformations of gia1 and the mechanism of gtp hydrolysis
1git		Structure of gtp-binding protein
1got		Heterotrimeric complex of a gt-alpha/gi-alpha chimera and the gt-beta-gamma subunits
1gp2		G protein heterotrimer gi_alpha_1 beta_1 gamma_2 with gdp bound
1kjy		Crystal structure of human g[alpha]i1 bound to the goloco motif of rgs14
1shz		Crystal structure of the p115rhogef rgrgs domain in a complex with galpha(13):galpha(i1) chimera
1svk		Structure of the k180p mutant of gi alpha subunit bound to alf4 and gdp
1svs		Structure of the k180p mutant of gi alpha subunit bound to gppnhp.
1tad		Gtpase mechanism of gproteins from the 1.7-angstrom crystal structure of transducin alpha-gdp-alf4-
1tag		Structural determinants for activation of the alpha-subunit of a heterotrimeric g protein
1tl7		Complex of gs- with the catalytic domains of mammalian adenylyl cyclase: complex with 2'(3')-o-(n- methylanthraniloyl)-guanosine 5'-triphosphate and mn
1tnd		The 2.2 angstroms crystal structure of transducin-alpha complexed with gtp gamma s
1u0h		Structural basis for the inhibition of mammalian adenylyl cyclase by mant-gtp
1y3a		Structure of g-alpha-i1 bound to a gdp-selective peptide provides insight into guanine nucleotide exchange
1zca		Crystal structure of g alpha 12 in complex with gdp, mg2+ and alf4-
1zcb		Crystal structure of g alpha 13 in complex with gdp
2bcj		Crystal structure of g protein-coupled receptor kinase 2 in complex with galpha-q and gbetagamma subunits
2ebc		Mechanism underlying the critical contribution of a switch ii residue in a heterotrimeric g-protein alpha subunit during c. elegans asymmetric cell division
2g83		Structure of activated g-alpha-i1 bound to a nucleotide- state-selective peptide: minimal determinants for recognizing the active form of a g protein alpha subunit
2gtp		Crystal structure of the heterodimeric complex of human rgs1 and activated gi alpha 1
2gvd		Complex of gs- with the catalytic domains of mammalian adenylyl cyclase: complex with tnp-atp and mn
2gvz		Crystal structure of complex of gs- with the catalytic domains of mammalian adenylyl cyclase: complex with mant- atp and mn
2hlb		A structural basis for nucleotide exchange on g-alpha-i subunits and receptor coupling specificity
2ihb		Crystal structure of the heterodimeric complex of human rgs10 and activated gi alpha 3
2ik8		Crystal structure of the heterodimeric complex of human rgs16 and activated gi alpha 1
2ode		Crystal structure of the heterodimeric complex of human rgs8 and activated gi alpha 3
2om2		Crystal structure of human g[alpha]i1 bound to the goloco motif of rgs14
2pz2		Crystal structure of the gdp-bound conformation of a g- alpha-i1 mutant with enhanced gtpase activity
2pz3		Crystal structure of the amf-bound conformation of a g- alpha-i1 mutant with enhanced gtpase activity
2rgn		Crystal structure of p63rhogef complex with galpha-q and rhoa
2v4z
2zjy
2zjz
3c14
3c15
3c16
3c7k		Molecular architecture of galphao and the structural basis for rgs16-mediated deactivation
3cx6
3cx7
3cx8
3d7m
3e8a
3ffa
3ffb

Links (links to other resources describing this domain)
PFAM G-alpha