HintNHint (Hedgehog/Intein) domain N-terminal region |
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| SMART accession number: | SM00306 |
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| Description: | Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases. |
| Interpro abstract (IPR003587): | This domain is found in sequences, which belong to MEROPS peptidase family C46 (clan, CH). The type example is the hedgehog protein of Drosophila melanogaster which self-processes by a cysteine dependent mechanism. Hedgehog proteins are involved in intracellular signalling required for a variety of patterning events during development. The hint domain is found in these proteins, as well as several proteins which contain inteins and undergo protein splicing. These include the V-type ATP synthase alpha chain from Pyrococcus and the Guillardia replicative DNA helicase DNAB. The Hedgehog/Intein domain has been split to accommodate large insertions of endonucleases. This entry is the N-terminal region. |
| Family alignment: |
There are 500 HintN domains in 452 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
- Disease (disease genes where sequence variants are found in this domain)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)
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