Histone H4
SMART accession number:SM00417
Description: -
Interpro abstract (IPR001951):

Histone H4 is one of the five histones, along with H1/H5, H2A, H2B and H3. Two copies of each of the H2A, H2B, H3, and H4 histones ensemble to form the core of the nucleosome [(PUBMED:16472024)]. The nucleosome forms octameric structure that wraps DNA in a left-handed manner. H3 is a highly conserved protein of 135 amino acid residues [(PUBMED:8121801), (PUBMED:2041803)]. Histones can undergo several different types of post-translational modifications that affect transcription, DNA repair, DNA replication and chromosomal stability. The sequence of histone H4 has remained almost invariant in more then 2 billion years of evolution [(PUBMED:8121801), (PUBMED:6808351), (PUBMED:3340182)].

GO component:nucleus (GO:0005634), nucleosome (GO:0000786)
GO function:DNA binding (GO:0003677)
Family alignment:
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There are 2776 H4 domains in 2524 proteins in SMART's nrdb database.

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