Histone H3
SMART accession number:SM00428
Description: -
Interpro abstract (IPR000164):

Histone H3 is one of the four histones, along with H2A, H2B and H4, which form the eukaryotic nucleosome octomer core [(PUBMED:8121801)]; the nucleosome octamer winds ~146 DNA base-pairs. It is a highly conserved protein of 135 amino acid residues [(PUBMED:8121801), (PUBMED:2041803)].

Several proteins have been found to contain a C-terminal H3-like domain, including the mammalian centromeric protein CENP-A (which may act as a core histone necessary for the assembly of centromeres) [(PUBMED:7962047)]; yeast chromatin- associated protein CSE4 [(PUBMED:7698647)]; and Caenorhabditis elegans chromosome III proteins YL82_CAEEL and YMH3_CAEEL, whose function is unknown.

GO process:nucleosome assembly (GO:0006334)
GO component:nucleosome (GO:0000786)
GO function:DNA binding (GO:0003677)
Family alignment:
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There are 5444 H3 domains in 3722 proteins in SMART's nrdb database.

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