H15Domain in histone families 1 and 5 |
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| SMART accession number: | SM00526
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| Description: |
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| Interpro abstract (IPR005818): |
Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures. Histone H5 performs the same function as histone H1, and replaces H1 in certain cells. The structure of GH5, the globular domain of the linker histone H5 is known (PUBMED:8384699), (PUBMED:3463990). The fold is similar to the DNA-binding domain of the catabolite gene activator protein, CAP, thus providing a possible model for the binding of GH5 to DNA.
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| GO process: | nucleosome assembly (GO:0006334) |
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| GO component: | nucleus (GO:0005634), nucleosome (GO:0000786) |
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| GO function: | DNA binding (GO:0003677) |
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| Family alignment: |
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There are 744
H15 domains in 679 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Luger K, Richmond TJ
- DNA binding within the nucleosome core.
- Curr Opin Struct Biol. 1998; 8: 33-40
- Display abstract
The high resolution structure of the nucleosome core particle of chromatin reveals the form of DNA that is predominant in living cells and offers a wealth of information on DNA binding and bending by the histone octamer. Recent studies imply that chromatin is highly dynamic. This propensity for unfolding and refolding stems from the structural design of the nucleosome core. The histone-fold motif, central to nucleosome structure, is also found in other proteins involved in transcriptional regulation.
- Structure (3D structures containing this domain)
3D Structures of H15 domains in PDB
| PDB code | Main view | Title | | 1ghc |  | Homo-and heteronuclear two-dimensional nmr studies of the globular domain of histone h1: full assignment, tertiary structure, and comparison with the globular domain of histone h5 |
| 1hst |  | Crystal structure of globular domain of histone h5 and its implications for nucleosome binding |
| 1uhm |  | Solution structure of the globular domain of linker histone homolog hho1p from s. cerevisiae |
| 1uss |  | Yeast histone h1 globular domain ii, hho1p gii, solution nmr structures |
| 1ust |  | Yeast histone h1 globular domain i, hho1p gi, solution nmr structures |
| 1yqa |  | Engineering the structural stability and functional properties of the gi domain into the intrinsically unfolded gii domain of the yeast linker histone hho1p |
- Links (links to other resources describing this domain)
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to expand nodes. To display all proteins with a H15 domain in a specific node, click on it.
