CPDccatalytic domain of ctd-like phosphatases |
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| SMART accession number: | SM00577
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| Description: |
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| Interpro abstract (IPR004274): |
The function of this domain is unclear. It is found in proteins of diverse function including phosphatases some of which may be active in active in ternary elongation complexes and a number of NLI interacting factors. In the phospatases this domain is often present N-terminal to the BRCT domain (IPR001357).
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| Family alignment: |
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There are 956
CPDc domains in 955 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Cellular role (predicted cellular role)
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Binding / catalysis: phosphatase
- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Doerks T, Copley RR, Schultz J, Ponting CP, Bork P
- Systematic identification of novel protein domain families associated with nuclear functions.
- Genome Res. 2002; 12: 47-56
- Display abstract
A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.
- Structure (3D structures containing this domain)
3D Structures of CPDc domains in PDB
| PDB code | Main view | Title | | 1t9z |  | Three-dimensional structure of a rna-polymerase ii binding protein. |
| 1ta0 |  | Three-dimensional structure of a rna-polymerase ii binding protein with associated ligand. |
| 2ghq |  | Ctd-specific phosphatase scp1 in complex with peptide c- terminal domain of rna polymerase ii |
| 2ght |  | Ctd-specific phosphatase scp1 in complex with peptide from c-terminal domain of rna polymerase ii |
| 2hhl |  | Crystal structure of the human small ctd phosphatase 3 isoform 1 |
| 2q5e |  | Crystal structure of human carboxy-terminal domain rna polymerase ii polypeptide a small phosphatase 2 |
| 3ef0 |  | |
| 3ef1 |  | |
- Links (links to other resources describing this domain)
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to expand nodes. To display all proteins with a CPDc domain in a specific node, click on it.
