Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2008) Nucleic Acids Res , doi:10.1093/nar/gkn808

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calpain_III

There are 476 calpain_III domains in 448 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a calpain_III domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with calpain_III domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Cellular role (predicted cellular role)

• Cellular role: signalling
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• % proteins involved KEGG pathway ID Description 67.86 map04210 Apoptosis 32.14 map04510 Focal adhesion This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with calpain_III domain which could be assigned to a KEGG orthologous group, and not all proteins containing calpain_III domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of calpain_III domains in PDB

  PDB code	Main view	Title
  1df0		Crystal structure of m-calpain
  1kfu		Crystal structure of human m-calpain form ii
  1kfx		Crystal structure of human m-calpain form i
  1qxp		Crystal structure of a mu-like calpain
  1u5i		Crystal structure analysis of rat m-calpain mutant lys10 thr
  2qfe		Distal c2-like domain of human calpain-7
  3bow
  3df0

• Links (links to other resources describing this domain)

• PFAM	Calpain_III