FABDF-actin binding domain (FABD)
|SMART accession number:||SM00808|
|Description:||FABD is the F-actin binding domain of Bcr-Abl and its cellular counterpart c-Abl. The Bcr-Abl tyrosine kinase causes different forms of leukemia in humans. Depending on its position within the cell, Bcr-Abl differentially affects cellular growth. The FABD forms a compact left-handed four-helix bundle in solution.|
|Interpro abstract (IPR015015):|
The F-actin binding domain forms a compact bundle of four antiparallel alpha-helices, which are arranged in a left-handed topology. Binding of F-actin to the F-actin binding domain may result in cytoplasmic retention and subcellular distribution of the protein, as well as possible inhibition of protein function [(PUBMED:16109371)].
|GO process:||protein phosphorylation (GO:0006468)|
|GO function:||non-membrane spanning protein tyrosine kinase activity (GO:0004715), ATP binding (GO:0005524)|
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