SMART: PGAM domain annotation

PGAM Phosphoglycerate mutase family

SMART accession number:	SM00855
Description:	Phosphoglycerate mutase (PGAM) and bisphosphoglycerate mutase (BPGM) are structurally related enzymes that catalyse reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate (PUBMED:2847721), (PUBMED:2831102), (PUBMED:10958932). Both enzymes can catalyse three different reactions with different specificities, the isomerization of 2-phosphoglycerate (2-PGA) to 3-phosphoglycerate (3-PGA) with 2,3-diphosphoglycerate (2,3-DPG) as the primer of the reaction, the synthesis of 2,3-DPG from 1,3-DPG with 3-PGA as a primer and the degradation of 2,3-DPG to 3-PGA (phosphatase activity). In mammals, PGAM is a dimeric protein with two isoforms, the M (muscle) and B (brain) forms. In yeast, PGAM is a tetrameric protein.
Family alignment:	View or

There are 6602 PGAM domains in 3261 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with PGAM domain is also avaliable.

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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
Cellular role (predicted cellular role)
Cellular role: metabolism
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Tallaksen-Greene SJ, Kaatz KW, Romano C, Albin RL
- Localization of mGluR1a-like immunoreactivity and mGluR5-likeimmunoreactivity in identified populations of striatal neurons.
- Brain Res. 1998; 780: 210-7
- Display abstract
- Metabotropic glutamate receptors are important mediators of excitatoryamino acid neurotransmission in the striatum. Two-color immunofluorescencehistochemistry and immunohistochemistry in combination with retrogradetract-tracing techniques were used to examine the distribution ofmetabotropic glutamate receptor subtypes 1a and 5 (mGluR1a and mGluR5)among identified subpopulations of striatal projection neurons andinterneurons. The majority of striatopallidal and striatonigral neuronswere double-labeled for both mGluR1a or mGluR5. Approximately 60% to 70%of either striatonigral or striatopallidal neurons expressed mGluR1a- ormGluR5-like immunoreactivity. The percentage of double-labeledstriatopallidal or striatonigral projection neurons did not differ amongstriatal quadrants. Striatal interneurons expressing parvalbumin orsomatostatin or choline acetyltransferase exhibited varying degrees ofexpression of mGluR1a or mGluR5. Virtually all (94%)parvalbumin-immunoreactive striatal neurons expressed mGluR1a-likeimmunoreactivity with a majority (79%) of these neurons expressingmGluR5-like immunoreactivity. A high percentage (89%) of striatal cholineacetyltransferase-immunoreactive neurons were double-labeled formGluR1a-like immunoreactivity. Approximately 65% of striatal cholineacetyltransferase-immunoreactive neurons expressed mGluR5-likeimmunoreactivity. A majority (65%) of somatostatin-immunoreactive striatalinterneurons expressed mGluR1a-like immunoreactivity with a slightly lowerpercentage (55%) expressing mGluR5-like immunoreactivity. These findingsindicate considerable heterogeneity among striatal projection andinterneurons with respect to mGluR1a and mGluR5 expression. There may besubpopulations of striatonigral and striatopallidal projection neurons.These results are consistent as well with prior data indicatingsubpopulations of the different classes of striatal interneurons.
Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

3D Structures of PGAM domains in PDB

PDB code	Main view	Title
1bif		6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase bifunctional enzyme complexed with atp-g-s and phosphate
1bq3		Saccharomyces cerevisiae phosphoglycerate mutase in complex with inositol hexakisphosphate
1bq4		Saccharomyces cerevisiae phosphoglycerate mutase in complex with benzene hexacarboxylate
1c7z		Regulatory complex of fructose-2,6-bisphosphatase
1c80		Regulatory complex of fructose-2,6-bisphosphatase
1c81		Michaelis complex of fructose-2,6-bisphosphatase
1e58		E.coli cofactor-dependent phosphoglycerate mutase
1e59		E.coli cofactor-dependent phosphoglycerate mutase complexed with vanadate
1ebb		Bacillus stearothermophilus yhfr
1fbt		The bisphosphatase domain of the bifunctional rat liver 6- phosphofructo-2-kinase/fructose-2,6-bisphosphatase
1fzt		Solution structure and dynamics of an open b-sheet, glycolytic enzyme-monomeric 23.7 kda phosphoglycerate mutase from schizosaccharomyces pombe
1h2e		Bacillus stearothermophilus phoe (previously known as yhfr) in complex with phosphate
1h2f		Bacillus stearothermophilus phoe (previously known as yhfr) in complex with trivanadate
1k6m		Crystal structure of human liver 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatase
1qhf		Yeast phosphoglycerate mutase-3pg complex structure to 1.7 a
1rii		Crystal structure of phosphoglycerate mutase from m. tuberculosis
1t8p		Crystal structure of human erythrocyte 2,3- bisphosphoglycerate mutase
1tip		The bisphosphatase domain of the bifunctional rat liver 6- phosphofructo-2-kinase/fructose-2,6-bisphosphatase
1ujb		Structure of the protein histidine phosphatase sixa
1ujc		Structure of the protein histidine phosphatase sixa complexed with tungstate
1v37		Crystal structure of phosphoglycerate mutase from thermus thermophilus hb8
1v7q		Crystal structure of phosphoglycerate mutase from thermus thermophilus hb8
1xq9		Structure of phosphoglycerate mutase from plasmodium falciparum at 2.6 resolution
1yfk		Crystal structure of human b type phosphoglycerate mutase
1yjx		Crystal structure of human b type phosphoglycerate mutase
2a6p		Structure solution to 2.2 angstrom and functional characterisation of the open reading frame rv3214 from mycobacterium tuberculosis
2a9j		Human bisphosphoglycerate mutase complexed with 3- phosphoglycerate (17 days)
2axn		Crystal structure of the human inducible form 6- phosphofructo-2-kinase/fructose-2,6-bisphosphatase
2bif		6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase h256a mutant with f6p in phosphatase active site
2dwo		Pfkfb3 in complex with adp and pep
2dwp		A pseudo substrate complex of 6-phosphofructo-2-kinase of pfkfb
2ekb		Structural study of project id tthb049 from thermus thermophilus hb8 (l19m)
2ekz		Structural study of project id tthb049 from thermus thermophilus hb8 (l52m)
2enu		Mutant l121m structure of tthb049 from thermus thermophilus hb8
2enw		Mutant y92h structure of tthb049 from thermus thermophilus hb8
2eoa		Structural study of project id tthb049 from thermus thermophilus hb8 (w85h)
2f90		Crystal structure of bisphosphoglycerate mutase in complex with 3-phosphoglycerate and alf4-
2h4x		Human bisphosphoglycerate mutase complex with 3- phosphoglycerate with crystal growth 90 days
2h4z		Human bisphosphoglycerate mutase complexed with 2,3- bisphosphoglycerate
2h52		Crystal structure of human bisphosphoglycerate mutase complex with 3-phosphoglycerate (18 days)
2hhj		Human bisphosphoglycerate mutase complexed with 2,3- bisphosphoglycerate (15 days)
2hia		Crystal structure of tthb049 from thermus thermophilus hb8
2i1v		Crystal structure of pfkfb3 in complex with adp and fructose-2,6-bisphosphate
2owd		Crystal structure of tthb049 from thermus thermophilus hb8
2owe		Crystal structure of tthb049 from thermus thermophilus hb8
2p2y		Crystal structure of tthb049 from thermus thermophilus hb8
2p2z		Crystal structure of tthb049 from thermus thermophilus hb8
2p30		Crystal structure of tthb049 from thermus thermophilus hb8
2p6m		Crystal structure of tthb049 from thermus thermophilus hb8
2p6o		Crystal structure of tthb049 from thermus thermophilus hb8
2p75		Crystal structure of tthb049 from thermus thermophilus hb8
2p77		Crystal structure of tthb049 from thermus thermophilus hb8
2p78		Crystal structure of tthb049 from thermus thermophilus hb8
2p79		Crystal structure of tthb049 from thermus thermophilus hb8
2p9f		Crystal structure of tthb049 from thermus thermophilus hb8
2p9y		Crystal structure of tthb049 from thermus thermophilus hb8
2p9z		Crystal structure of tthb049 from thermus thermophilus hb8
2pa0		Crystal structure of tthb049 from thermus thermophilus hb8
2rfl		Crystal structure of the putative phosphohistidine phosphatase sixa from agrobacterium tumefaciens
3bif		6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase empty 6-pf-2k active site
3d8h		Crystal structure of phosphoglycerate mutase from cryptosporidium parvum, cgd7_4270
3dcy		Crystal structure a tp53-induced glycolysis and apoptosis regulator protein from homo sapiens.
3e9c
3e9d
3e9e
3eoz
3ezn
3f2i
3f3k
3fdz
3fjy
3gp3
3gp5
3gw8
3hjg
3kkk
3pgm		The structure of yeast phosphoglycerate mutase at 0.28 nm resolution
4pgm		Saccharomyces cerevisiae phosphoglycerate mutase
5pgm		Saccharomyces cerevisiae phosphoglycerate mutase

Links (links to other resources describing this domain)
PFAM PGAM