SMART accession number:SM01272
Description: This domain is found associated with Lsm domain PMID:16115810.
Interpro abstract (IPR009604):

This entry represents a conserved region approximately 250 residues long located on eukaryotic ataxin-2 [(PUBMED:16115810)]. Ataxin-2 is a protein of unknown function, within which expansion of a polyglutamine tract (due to expansion of unstable CAG repeats in the coding region of the SCA2 gene) causes spinocerebellar ataxia type 2 (SCA2), a late-onset neurodegenerative disorder [(PUBMED:9339681)]. The expanded polyglutamine repeat in ataxin-2 causes disruption of the normal morphology of the Golgi complex and increased incidence of cell death [(PUBMED:12812977)]. Ataxin-2 is predicted to consist of mostly non-globular domains [(PUBMED:9462862)].

Family alignment:
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There are 2461 LsmAD domains in 2455 proteins in SMART's nrdb database.

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