SMART: Mago-bind domain annotation

Mago-bind Mago binding

SMART accession number:	SM01273
Description:	Members of this family adopt a structure consisting of a small globular all-beta-domain, with a three-stranded beta-sheet and a contiguous beta-hairpin. They bind to Mago alpha-helices via extensive electrostatic interactions and at a beta2-beta3 loop via hydrophobic interactions PMID:14968132.
Interpro abstract (IPR015362):	Partner of Y14 and mago (PYM, also known as WIBG) is a key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation [ (PUBMED:18026120) (PUBMED:19410547) ]. The N-terminal domain of PYM adopts a small globular all-beta-domain structure, with a three-stranded beta-sheet and a contiguous beta-hairpin. It binds to both Mago and Y14 [ (PUBMED:14968132) ].
Family alignment:	View or

There are 1405 Mago-bind domains in 1383 proteins in SMART's nrdb database.

Click on the following links for more information.

Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing Mago-bind domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Mago-bind domain is also avaliable.

Click on the protein counts, or double click on taxonomic names to display all proteins containing Mago-bind domain in the selected taxonomic class.
Structure (3D structures containing this domain)
3D Structures of Mago-bind domains in PDB
PDB code Main view Title
1rk8 Structure of the cytosolic protein PYM bound to the Mago-Y14 core of the exon junction complex
Links (links to other resources describing this domain)
INTERPRO IPR015362
PFAM Mago-bind

INTERPRO	IPR015362
PFAM	Mago-bind

Mago-bind