Frizzled/Smoothened family membrane region
SMART accession number:SM01330
Description: Frizzled is a family of G protein-coupled receptor proteins (PMID: 14977528) that serves as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol.
Interpro abstract (IPR000539):

This domain is the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled (P18537) are receptors for Wnt (mediating the beta-catenin signalling pathway) [(PUBMED:8717036)], but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding [(PUBMED:15239825)]. The smoothened receptor mediates hedgehog signalling [(PUBMED:9811578)].

GO process:cell surface receptor signaling pathway (GO:0007166)
GO component:membrane (GO:0016020)
Family alignment:
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There are 5099 Frizzled domains in 5097 proteins in SMART's nrdb database.

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