SMART: A2M_N_2 domain annotation

A2M_N_2 Alpha-2-Macroglobulin

SMART accession number:	SM01359
Description:	This family includes a region of the alpha-2-macroglobulin family.
Interpro abstract (IPR011625):	Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region [ (PUBMED:25221932) (PUBMED:22290936) ]. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognised as the Venus flytrap mechanism [ (PUBMED:25221932) ].
Family alignment:	View or

There are 13783 A2M_N_2 domains in 13732 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing A2M_N_2 domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with A2M_N_2 domain is also avaliable.

Click on the protein counts, or double click on taxonomic names to display all proteins containing A2M_N_2 domain in the selected taxonomic class.
Structure (3D structures containing this domain)

3D Structures of A2M_N_2 domains in PDB

PDB code	Main view	Title
2a73		Human Complement Component C3
2a74		Human Complement Component C3c
2b39		Structure of mammalian C3 with an intact thioester at 3A resolution
2i07		Human Complement Component C3b
2ice		CRIg bound to C3c
2icf		CRIg bound to C3b
2pn5		Crystal Structure of TEP1r
2qki		Human C3c in complex with the inhibitor compstatin
2wii		Complement C3b in complex with factor H domains 1-4
2win		C3 convertase (C3bBb) stabilized by SCIN
2xwb		Crystal Structure of Complement C3b in complex with Factors B and D
2xwj		Crystal Structure of Complement C3b in Complex with Factor B
3cu7		Human Complement Component 5
3frp		Crystal Structure of Cobra Venom Factor, a Co-factor for C3- and C5 convertase CVFBb
3g6j		C3b in complex with a C3b specific Fab
3hrz		Cobra Venom Factor (CVF) in complex with human factor B
3hs0		Cobra Venom Factor (CVF) in complex with human factor B
3kls		Structure of complement C5 in complex with SSL7
3km9		Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7
3l3o		Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3c
3l5n		Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3b
3nms		Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement C3c
3ohx		Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b
3prx		Structure of Complement C5 in Complex with CVF and SSL7
3pvm		Structure of Complement C5 in Complex with CVF
3t4a		Structure of a truncated form of Staphylococcal Complement Inhibitor B bound to human C3c at 3.4 Angstrom resolution
4a5w		Crystal structure of C5b6
4acq		Alpha-2 Macroglobulin
4d94		Crystal Structure of TEP1r
4e0s		Crystal Structure of C5b-6
4fxg		Complement C4 in complex with MASP-2
4fxk		Human complement C4
4lnv		Crystal Structure of TEP1s
4rtd		4RTD
4u48		4U48
4u4j		4U4J
4u59		4U59
4xam		4XAM
4ziq		4ZIQ
5a42		5A42
5fo7		5FO7
5fo8		5FO8
5fo9		5FO9
5foa		5FOA
5fob		5FOB
5hcc		5HCC
5hcd		5HCD
5hce		5HCE
5i5k		5I5K
5jpm		5JPM
5jpn		5JPN
5jtw		5JTW

Links (links to other resources describing this domain)
PFAM A2M_N_2
INTERPRO IPR011625

PFAM	A2M_N_2
INTERPRO	IPR011625

A2M_N_2

Taxonomic distribution of proteins containing A2M_N_2 domain.

3D Structures of A2M_N_2 domains in PDB