SMART accession number:SM01398
Description: -
Interpro abstract (IPR003377):

This entry represents a group of conserved proteins from fungi, plants to animals. They are transmembrane proteins. Proteins in this entry include budding yeast Erv14/15, Drosophila Cornichon and human CNIH1/2/3/4.

The drosophila cornichon protein (gene: cni), the founding member of this family, is an integral component of the COPII-coated vesicles that mediate cargo export from the yeast endoplasmic reticulum (ER) [(PUBMED:16396907)]. It is required in the germline for dorsal-ventral signalling. The dorsal-ventral pattern formation involves a reorganisation of the microtubule network correlated with the movement of the oocyte nucleus, and depending on the initial correct establishment of the anterior-posterior axis via a signal from the oocyte produced by cornichon and gurken and received by torpedo protein in the follicle cells [(PUBMED:7540118)].

Erv14 is a COPII-coated vesicle protein involved in vesicle formation and incorporation of specific secretory cargo. It is required for axial budding [(PUBMED:9732282), (PUBMED:17298976)].

CNIH1 is involved in the selective transport and maturation of TGF-alpha family proteins [(PUBMED:17607000)].

GO process:vesicle-mediated transport (GO:0016192)
Family alignment:
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There are 2887 Cornichon domains in 2887 proteins in SMART's nrdb database.

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