Sybindin

Sybindin-like family
Sybindin
SMART accession number:SM01399
Description: Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses PMID:11018053.
Interpro abstract (IPR007233):

This entry includes a group of trafficking protein particle complex subunit (TRAPPC) proteins, such as TPPC1/4 from humans and Trs23/Bet5 from yeasts.

Budding yeast Trs23 and Bet5 are components of the TRAPP I, TRAPP II and TRAPP III. TRAPP complexes are guanine nucleotide exchange factors (GEF) for the GTPase Ypt1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. RAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation [(PUBMED:11239471), (PUBMED:20972447), (PUBMED:20375281)].

GO process:vesicle-mediated transport (GO:0016192)
GO component:TRAPP complex (GO:0030008)
Family alignment:
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There are 2891 Sybindin domains in 2890 proteins in SMART's nrdb database.

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