TNFTumour necrosis factor family.
|SMART accession number:||SM00207|
|Description:||Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.|
|Interpro abstract (IPR006052):|
Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [(PUBMED:8095800), (PUBMED:1377364), (PUBMED:15335677)]. Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a monocyte-derived cytotoxin that has been implicated in tumour regression, septic shock and cachexia [(PUBMED:2989794), (PUBMED:3349526)]. The protein is synthesised as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine [(PUBMED:2268312)]. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers [(PUBMED:2777790)]. Both the mature protein and a partially-processed form of the hormone are secreted after cleavage of the propeptide [(PUBMED:2777790)].
There are a number of different families of TNF, but all these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors.
All these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors. The PROSITE pattern for this family is located in a beta-strand in the central section of the protein which is conserved across all members.
|GO process:||immune response (GO:0006955)|
|GO component:||membrane (GO:0016020)|
|GO function:||tumor necrosis factor receptor binding (GO:0005164)|
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