Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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TSPc tail specific protease

SMART accession number:	SM00245
Description:	tail specific protease
Interpro abstract (IPR005151):	This group of putative serine peptidases belong to the MEROPS peptidase family S41 (C-terminal processing peptidase family, clan SM). The members of this group include: the tricorn protease of bacteria and archaea, C-terminal peptidases with different substrates specificities in different species including processing of D1 protein of the photosystem II reaction centre in higher plants and cleavage of a peptide of 11 residues from the precursor form of penicillin-binding protein; and some appear to be responsible for degrading oligopeptides, probably derived from the proteasome.
GO process:	proteolysis (GO:0006508)
GO function:	serine-type peptidase activity (GO:0008236)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 3663 TSPc domains in 3592 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a TSPc domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with TSPc domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Arabidopsis thaliana, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Structure (3D structures containing this domain)

• 3D Structures of TSPc domains in PDB

  PDB code	Main view	Title
  1fc6		Photosystem ii d1 c-terminal processing protease
  1fc7		Photosystem ii d1 c-terminal processing protease
  1fc9		Photosystem ii d1 c-terminal processing protease
  1fcf		Photosystem ii d1 c-terminal processing protease
  1j7x		Crystal structure of a functional unit of interphotoreceptor retinoid-binding protein (irbp)
  1k32		Crystal structure of the tricorn protease
  1n6d		Tricorn protease in complex with tetrapeptide chloromethyl ketone derivative
  1n6e		Tricorn protease in complex with a tridecapeptide chloromethyl ketone derivative
  1n6f		Tricorn protease in complex with z-phe-diketo-arg-glu-phe
  3dja		Crystal structure of cpaf solved with mad
  3dor		Crystal structure of mature cpaf
  3dpm		Structure of mature cpaf complexed with lactacystin
  3dpn		Crystal structure of cpaf s499a mutant
  3k50		Crystal structure of putative s41 protease (yp_211611.1) from bacteroides fragilis nctc 9343 at 2.00 a resolution

• Links (links to other resources describing this domain)

• INTERPRO	IPR005151

Send comments to Ivica Letunic