eIF3_N

eIF3 subunit 6 N terminal domain
eIF3_N
SMART accession number:SM01186
Description: This is the N terminal domain of subunit 6 translation initiation factor eIF3.
Interpro abstract (IPR019010):

This entry represents the N-terminal domain of the eukaryotic translation initiation factor 3 subunit E. EIF3 is required in protein synthesis in mammalian cells and, together with other initiation factors, stimulates binding of initiator methionyl-tRNAi and mRNA to the 40S ribosomal subunit to form the 48 S initiation complex [(PUBMED:17322308)]. The eIF3 complex also prevents premature association of the 40 and 60 S ribosomal subunits and interacts with other initiation factors involved in start codon selection. EIF3 has at least 13 protein components (eIF3a-m or 1-13), where subunits h, i, k, and m are likely to be on the periphery of the complex [(PUBMED:17322308)]. Subunit 6 is produced by the int6 gene, one of the frequent integration sites for mouse mammary tumor viruses [(PUBMED:18502752)].

Family alignment:
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There are 1464 eIF3_N domains in 1464 proteins in SMART's nrdb database.

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